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FR 146801

structure in first source

Also Known As:

FR-146801; FR146801; N-(4-ethyl-3-hydroxyimino-6-methyl-5-nitro-3-heptenyl)-3-pyridinecarboxamide

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Nicotinic Acids: 13
      - Niacinamide: 2223
        FR 146801: 2
- Heterocyclic Acids
  - Nicotinic Acids: 13
    - Niacinamide: 2223
      - FR 146801: 2

Related Diseases

1.	Hypotension (Low Blood Pressure) 08/01/1997 - "However, only FK409 showed significant hypotensive effects immediately after oral administration even at 0.32 mg/kg; FR146801 and ISDN did not cause any significant hypotension at 10 mg/kg, suggesting that FK409 induces much more potent arterial vasodilation than other drugs. " 03/01/1998 - "FK409 suppressed thrombus formation significantly at 1.0 mg/kg, p.o., at which it induced significant hypotension, whereas FR146801 did not show any significant hypotensive effect even at 10 mg/kg, p.o. "
2.	Thrombosis (Thrombus) 03/01/1998 - "In the rat extracorporeal shunt model, FR146801 inhibited thrombus formation dose-dependently and its inhibition was significant at 10 mg/kg, p.o. " 03/01/1998 - "FK409 suppressed thrombus formation significantly at 1.0 mg/kg, p.o., at which it induced significant hypotension, whereas FR146801 did not show any significant hypotensive effect even at 10 mg/kg, p.o. "

Related Drugs and Biologics

1.	Dihydrotachysterol (AT 10)

Related Therapies and Procedures

1.	Oral Administration