dihydroceramide desaturase

04/17/2009 - "elegans from anoxia by HYL-2 ceramide synthase."
02/01/2005 - "However, the role of ceramide synthase in enhanced ceramide generation has not been previously examined in hypoxia-reoxygenation injury. "
02/01/2005 - "Ceramide synthase is essential for endonuclease-mediated death of renal tubular epithelial cells induced by hypoxia-reoxygenation."
08/01/1998 - "The inhibitor of ceramide synthase, fumonisin B1, provided a marked protection against chemical hypoxia-induced DNA strand breaks, DNA fragmentation and cell death. "
02/01/2005 - "A specific inhibitor of ceramide synthase, fumonisin B1 (50 microM), suppressed hypoxia-reoxygenation-induced ceramide generation and provided protection against hypoxia-reoxygenation-induced EndoG release, DNA fragmentation, and cell death. "

08/01/2023 - "The ceramide synthase (CERS/LASS) family: Functions involved in cancer progression."
03/27/2023 - "Ceramide synthase 1 (CERS1) participates in malignancy development, but its potential role in NSCLC BM remains unclear. "
01/01/2019 - "Clinical and pathological significance of Homo sapiens ceramide synthase 2 (CerS-2) in diverse human cancers."
03/01/2013 - "Homo sapiens longevity assurance homolog 2 of yeast LAG1 (LASS2), a metastasis suppressor gene of human cancer, is the most abundantly expressed member of the ceramide synthase gene family. "
02/01/2012 - "Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells."

01/01/2018 - "C18 ceramide, synthesized by ceramide synthase 1 (CerS1), is abundant in skeletal muscle and suggested to promote insulin resistance in humans. "
01/01/2019 - "Recent genetic mouse studies suggest that specific sphingolipid C16:0 ceramide produced by ceramide synthase 6 (CerS6) plays an important role in the development of insulin resistance. "
05/13/2011 - "Differential regulation of dihydroceramide desaturase by palmitate versus monounsaturated fatty acids: implications for insulin resistance."
01/01/2020 - "Herein I discuss the therapeutic potential of targeting certain ceramide synthase isoforms for the treatment of obesity, insulin resistance, steatohepatitis, and other metabolic disorders."
10/07/2014 - "Haploinsufficiency for ceramide synthase 2 (CerS2), the dominant isoform in the liver that preferentially makes very-long-chain (C22/C24/C24:1) ceramides, led to compensatory increases in long-chain C16-ceramides and conferred susceptibility to diet-induced steatohepatitis and insulin resistance. "

10/26/2023 - "Ceramide synthase 4 overexpression exerts oncogenic properties in breast cancer."
01/01/2010 - "We now study mRNA expression levels of the six ceramide synthase (CerS) genes in breast cancer tissue. "
05/01/2022 - "Previous investigations suggest that ceramide synthase 6 (CERS6) antisense RNA 1 (CERS6-AS1) acts as an oncogene in breast cancer; however, its role in colorectal cancer is unknown. "
10/01/2022 - "Ceramide synthase 6 antisense RNA 1 contributes to the progression of breast cancer by sponging miR-16-5p to upregulate ubiquitin-conjugating enzyme E2C."
01/01/2010 - "Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression."

07/01/2020 - "Previously it has been shown that ceramide synthase 6 and 2 influence colitis in several animal models with sometimes opposite effects. "
11/14/2017 - "Adoptive Transfer of Ceramide Synthase 6 Deficient Splenocytes Reduces the Development of Colitis."
01/01/2017 - "Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity."
01/01/2018 - "Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis."
12/01/2017 - "Ablation of ceramide synthase 2 exacerbates dextran sodium sulphate-induced colitis in mice due to increased intestinal permeability."