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8- (5- (5- amino- 2,4- dimethoxyphenyl)- 5- oxopentyl)- 1,3,8- triazaspiro(4.5)decane- 2,4- dione

5-HT(2C) receptor antagonist; structure in first source

Also Known As:

RS 102221; RS-102221

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - 8-(5-(5-amino-2,4-dimethoxyphenyl)-5-oxopentyl)-1,3,8-triazaspiro(4.5)decane-2,4-dione: 7

Experts

1.	Cao, Dong-Yuan: 1 article (01/2020)
2.	Li, Jia-Heng: 1 article (01/2020)
3.	Traub, Richard J: 1 article (01/2020)
4.	Wang, Mao-De: 1 article (01/2020)
5.	Wei, Si-Qi: 1 article (01/2020)
6.	Xu, Gang-Zhu: 1 article (01/2020)
7.	Xue, Yang: 1 article (01/2020)
8.	Elaidy, Samah M: 1 article (12/2016)
9.	Essawy, Soha S: 1 article (12/2016)
10.	Cervantes-Durán, Claudia: 1 article (04/2016)

Related Diseases

1.	Pulmonary Fibrosis (Fibrosing Alveolitis) 12/01/2016 - "The current study pointed to examine the antifibrotic effects of RS-102221 and/or terguride through in vivo model of pulmonary fibrosis. "
2.	Hyperalgesia 01/01/2020 - "The reversal of somatic hyperalgesia and visceral hypersensitivity by VPA in FS rats was blocked by intrathecal administration of the selective 5-HT2C receptor antagonist RS-102221 (30 μg/10 μL) 30 min after each VPA injection. " 04/01/2016 - "In contrast, intrathecal pre-treatment with the selective 5-HT2A (ketanserin 1-100nmol), 5-HT2B (RS 127445 1-100nmol) or 5-HT2C (RS 102221 1-100nmol) receptor antagonists prevented and reversed, respectively, 1% formalin-induced secondary allodynia and hyperalgesia in both paws. " 03/01/2013 - "Furthermore, ipsilateral pre-treatment (nmol/paw) with ketanserin (1, 10, and 100), RS-127445 (0.01, 0.1 and 1) or RS-102221 (1, 10 and 100) prevented while post-treatment reversed 1% formalin-induced secondary allodynia and hyperalgesia in both paws. "
3.	Lung Injury 12/01/2016 - "Either RS-102221 or terguride reduced the increments in lung water contents, grading of lung fibrosis, lung tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta1 (TGF-β1) and vascular endothelial growth factor (VEGF) levels in lung injury and fibrosis-induced by bleomycin. "
4.	Weight Gain 04/01/1997 - "Consistent with its action as a 5-HT2C receptor antagonist, daily dosing with RS-102221 (2 mg/kg intraperitoneal) increased food-intake and weight-gain in rats. "
5.	Inflammation (Inflammations) 01/01/2002 - "Furthermore, intrathecal administration of spiroxatrine, but not RS 102221 nor MDL 72222, significantly attenuated the increased hindpaw withdrawal latencies induced by intra-periaqueductal gray administration of morphine in rats with nerve injury and in rats with inflammation. "

Related Drugs and Biologics

1.	dironyl (terguride)
2.	5-HT2C Serotonin Receptor
3.	Ketanserin
4.	Formaldehyde (Formol)
5.	2- amino- 4- (4- fluoronaphth- 1- yl)- 6- isopropylpyrimidine
6.	Transforming Growth Factor beta1 (TGF beta 1)
7.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
8.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
9.	Serotonin Receptors
10.	Morphine (MS Contin)