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cirsimarin

a flavone glycoside from Microtea debilis; structure given in first source

Also Known As:

Cirsitakaoside; 2-(4-(beta-D-glucopyranosyloxy)phenyl)-5-hydroxy-6,7-dimethoxy-4H-1-benzopyran-4-one

Networked: 9 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycosides: 2119
  - cirsimarin: 9
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        cirsimarin: 9
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        cirsimarin: 9

Experts

1.	Chen, Weilin: 2 articles (09/2020 - 06/2018)
2.	Di, Qianqian: 2 articles (09/2020 - 06/2018)
3.	Pu, Debing: 2 articles (09/2020 - 06/2018)
4.	Xiao, Weilie: 2 articles (09/2020 - 06/2018)
5.	Zhao, Xibao: 2 articles (09/2020 - 06/2018)
6.	Zhu, Huihui: 2 articles (09/2020 - 06/2018)
7.	Camara, Marcos Bispo Pinheiro: 1 article (09/2022)
8.	Cólus, Ilce Mara de Syllos: 1 article (09/2022)
9.	Fujiike, Andressa: 1 article (09/2022)
10.	Oliveira, Larissa Cristina Bastos de: 1 article (09/2022)

Related Diseases

1.	Inflammation (Inflammations) 06/01/2018 - "These results suggest that cirsitakaoside has the potential anti-inflammatory effect for treatment of inflammation diseases." 06/01/2018 - "In vivo, we showed that cirsitakaoside could relieve LPS-induced inflammation response. " 09/01/2020 - "Our study indicates that Cirsitakaoside is a good candidate for the treatment of viral infection and inflammation-related diseases." 01/01/2019 - "Although cirsimarin, cirsimaritin and apigenin are components of CJM and can reduce inflammation, only apigenin effectively reduced Hif-2α expression and inhibited Hif-2α-induced MMP3, MMP13, ADAMTS4, IL-6 and COX-2 expression in articular chondrocytes. "
2.	Neoplasms (Cancer) 09/01/2022 - "The present study investigates the mechanisms underlying the in vitro antitumoral activity of cirsimarin (CIR 10 to 320 μM), a flavone extracted from the aerial parts of Scoparia dulcis L., on MCF-7 cells cultured in 2D and multicellular tumor spheroids (3D). " 01/29/2020 - "Various compounds were detected with known activities on cancer (polyphenols: Luteolin, apeginin, matairesinol), on metabolic diseases (polyphenols: cirsimarin, spiraeoside, 2,4-dihydroxyheptadec-16-ynyl acetate; amino acids: N-acetyl-L-tyrosine), or on antifouling (fatty acids: 13-decosenamide; cinnamic acids: 3-hydroxy-4-methoxycinnamic acid, alpha-cyano-4-hydroxycinnamic), which could be, in part, responsible for the observed bioactivities. "
3.	Virus Diseases (Viral Diseases) 09/01/2020 - "Our study indicates that Cirsitakaoside is a good candidate for the treatment of viral infection and inflammation-related diseases."
4.	Body Weight (Weight, Body) 10/28/2018 - "MESi exhibited the high content of phenolics and flavonoids as well as compounds like austricine, benzylglucosinolate, gossypin, justicidin B and cirsimarin were detected in LC-MS. In the acute toxicity study, oral administration of MESi did not cause any toxic effect and mortality up to 2000 mg/kg body weight in mice. "
5.	Proteinuria 06/01/1997 - "The use of this plant against "proteinuria" in traditional medicine in Suriname (South America) may be explained by the adenosine A1 antagonistic action of cirsimarin. " 11/01/1997 - "The results indicate that in the kidney and urinary tract the concentrations of cirsimaritin produced after ingestion of more than 8 mg kg-1 cirsimarin can be high enough to inhibit the interaction of adenosine with its receptors; this might explain the effectiveness of Microtea debilis preparations against proteinuria in traditional medicine."

Related Drugs and Biologics

1.	Flavonoids
2.	benzylglucosinolic acid
3.	justicidins
4.	flavone
5.	gossypin
6.	Adenosine (Adenocard)
7.	cirsimaritin
8.	Polyphenols
9.	Luteolin
10.	Apigenin

Related Therapies and Procedures

1.	Oral Administration
2.	Traditional Medicine (Folk Remedies)
3.	Therapeutics