tapasin

MW 48 kDa; involved in the assembly and function of multimeric MHC class I-TAP complexes; binds TAP1, TAP2, & MHC class I proteins;

Also Known As:

NGS17 protein, human; TAP binding protein (tapasin), human; TAP binding protein, mouse; TAP binding protein, rat; TAP-associated protein, human; TAPBP protein, human; TPSN protein, human; Tapasin protein, mouse; Tapbp protein, mouse; Tapbp protein, rat; tapasin protein, rat

Networked: 82 relevant articles (1 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - tapasin: 82
  - Membrane Proteins: 10078
    - Membrane Transport Proteins: 589
      - tapasin: 82

Experts

1.	Ferrone, Soldano: 14 articles (10/2017 - 05/2003)
2.	Seliger, Barbara: 7 articles (01/2020 - 05/2003)
3.	Garrido, Federico: 4 articles (01/2016 - 09/2003)
4.	Thuring, Camilla: 4 articles (12/2015 - 01/2014)
5.	Cresswell, Peter: 3 articles (11/2020 - 10/2010)
6.	Geironson, Linda: 3 articles (12/2015 - 01/2014)
7.	Paulsson, Kajsa M: 3 articles (12/2015 - 01/2014)
8.	Harabuchi, Yasuaki: 3 articles (04/2010 - 09/2003)
9.	Ogino, Takeshi: 3 articles (04/2010 - 09/2003)
10.	Jefferies, Wilfred A: 3 articles (12/2008 - 09/2005)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 05/01/2008 - "In this study, we take advantage of a human melanoma cell line in which TAP can be induced, but tapasin cannot. " 05/01/2008 - "In this study, we show that treatment with HDACi enhances the expression of molecules (TAP1, TAP2, LMP2, LMP7, Tapasin and MHC class I) involved in antigen processing and presentation via the MHC class I pathway in melanoma cells. " 10/01/2010 - "Here, we report on an alternate splice form of tapasin (tpsnΔEx3) derived from a human melanoma cell line that does not appear to be caused by mutations. " 10/01/2010 - "Identification of an alternate splice form of tapasin in human melanoma." 06/01/2003 - "Whereas 100% of melanomata in situ and 96.2% of primary melanomas with a Breslow index of <or=0.75 mm showed strong expression of tapasin, significant downregulation of tapasin was observed in 25% of primary melanomas with a Breslow index >0.75 mm as well as in 21.1% metastatic melanoma lesions. "
2.	Neoplasms (Cancer) 03/01/2008 - "The aim of this study is to examine if Tapasin (Tpn) plays a critical role in the escape of tumors from immunologic recognition. " 01/01/2022 - "This is important, as the level of tapasin expression can vary widely during different stages of the immune response against pathogens or cancer and is often the target for immune escape." 03/20/2020 - "The effects of cancer variants on ERp57 and tapasin components from the MHC-I pathway is less known, and they could have an impact on antigen presentation. " 10/01/2018 - "TAP and tapasin, both key players in the pathway, are frequently downregulated in human cancers, correlating with poor patient survival. " 01/01/2017 - "Tapasin expression is thus a key for CTL surveillance against human cancers."
3.	Infections 10/01/2016 - "The present study aimed to determine whether tapasin is associated with chronic HBV (CHB) infection. " 01/01/2015 - "Our study implicated that TAP2, HLA-DOA, HLA-DOB, and tapasin loci were novel candidate regions for susceptibility to HCV infection and viral clearance in the Chinese population. " 12/15/2020 - "HLA polymorphism and tapasin independence influence outcomes of HIV and dengue virus infection." 09/01/2013 - "In a European, but not a US, Caucasian population, the tapasin G allele was significantly associated with the outcome of HCV infection, being found in 82.5% of resolvers versus 71.3% of persistently infected individuals (P = 0.02, odds ratio [OR] = 1.90 95% confidence interval [CI] = 1.11-3.23). " 09/01/2013 - "Patients with resolved or chronic HCV infection were genotyped for the known G/C coding polymorphism in exon 4 of the tapasin gene. "
4.	Squamous Cell Carcinoma of Head and Neck 01/01/2011 - "In this study, we investigated the expression of TAP-1 and tapasin in oral squamous cell carcinoma (OSCC); the result indicated significant down-regulation in the expression of these genes. " 10/01/2010 - "The aim of this study was to investigate the expression of tapasin in primary oral squamous cell carcinoma (OSCC) and its potential clinical implication. " 10/01/2010 - "Downregulation of tapasin expression in primary human oral squamous cell carcinoma: association with clinical outcome." 02/02/2001 - "Using the reverse transcription PCR, we evaluated expression levels of various antigen presentation-related genes, including LMP2, LMP7, MECL-1, PA28alpha, PA28beta, TAP1, TAP2, and tapasin, in two oral squamous cell carcinoma cell lines, HSC5 and HSC7. " 09/01/2011 - "To investigate the expression of antigen processing-1 (Tap-1) and Tapasin in oral squamous cell carcinoma (OSCC), and observe the immune response against OSCC by use of IFN-γ-antigen induced dendritic cells (DCs) in vitro and in vivo. "
5.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/01/2017 - "In the present study, we assessed tapasin expression in 85 primary tumor lesions of non-small cell lung cancer (NSCLC) patients, demonstrating that tapasin expression positively correlated with patient survival. " 09/01/2005 - "The present study examines the expression of HLA, tapasin, transporter associated with antigen processing 1 (TAP1), and beta2 microglobulin in human small cell lung carcinoma and non-small cell lung carcinoma. " 01/01/2020 - "Ab: antibody; ACTB: β-actin; APM: antigen processing and presentation machinery; ATCC: American tissue culture collection; β2-m: β2-microglobulin; BSA: bovine serum albumin; CTL: cytotoxic T lymphocyte; FCS: fetal calf serum; FFL: firefly luciferase; FFPE: formalin-fixed paraffin-embedded; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; HC: heavy chain; HLA: human leukocyte antigen; HLA-I: HLA class I; HRP: horseradish peroxidase; IFN: interferon; im-miR: immune modulatory miRNA; LMP: low molecular weight protein; luc: luciferase; MFI: mean fluorescence intensity; MHC: major histocompatibility complex; miR: microRNA; NC: negative control; NK: natural killer; NSCLC: non-small cell lung carcinoma; OS: overall survival; PBMC: peripheral blood mononuclear cells; RBP: RNA-binding proteins; RL: Renilla; RLU: relative light units; TAP: transporter associated with antigen processing; tpn: tapasin; UTR: untranslated region."

Related Drugs and Biologics

1.	Chemokines
2.	Histocompatibility Antigens Class I
3.	Peptides (Polypeptides)
4.	transporter associated with antigen processing (TAP)
5.	HLA-B Antigens (HLA-B)
6.	Poly I-C
7.	Ligands
8.	HLA-DM antigens (HLA-DMA)
9.	Proteins (Proteins, Gene)
10.	Calnexin

Related Therapies and Procedures

1.	Immunotherapy