deguelin

01/01/2008 - "Considering that HIF-1alpha is overexpressed in a majority of human cancers, deguelin could offer a potent therapeutic agent for cancer."
01/01/2019 - "An analysis of evidence from both in vitro and in vivo studies suggests that deguelin displays potent anticancer activity against multiple cancer types and exhibits chemopreventive potential in Akt-inducible transgenic mouse models. "
01/01/2017 - "In vivo studies, found that in immunodeficient nu/nu mice bearing H460 tumor xenografts showed that the deguelin significantly suppressed tumor growth. "
08/22/2013 - "In the present study, we aimed to evaluate the anti-metastatic potential of deguelin in vivo and in tumor growth factor-β1 (TGFβ1)-stimulated cells. "
03/01/2013 - "In pre-clinical trials, deguelin markedly decreased the tumor incidence. "

11/01/2009 - "Hence, the aim of the present study was to assess the therapeutic efficacy of deguelin, a rotenoid isolated from several plant species, which has been reported to have chemopreventive and/or chemotherapeutic effects in skin, mammary, colon, and lung cancers. "
01/01/2018 - "In the present study, we investigated the effect of deguelin on the cell adhesion, migration and invasion of NCI-H292 human lung cancer cells in vitro. "
05/16/2017 - "Thus, deguelin appears to be a promising new therapeutic agent for lung cancer and may be considered for further studies in other animal models and in clinical trials."
01/01/2017 - "In vitro studies, found that deguelin induced cell morphological changes, and decreased the percentage of viability through the induction of apoptosis in H460 lung cancer cells. "
01/01/2015 - "In this study, we investigated the effects of Deguelin on the cell invasion in human lung cancer A549 and H460 cells. "

03/10/2003 - "In a second study, the ability of deguelin to block the initiation and promotion stages of colon carcinogenesis was investigated. "
01/01/2021 - "The anticancer potential of deguelin with respect to its efficacy in targeting tumorigenesis via nanotechnological approaches is also investigated. "
01/01/2020 - "By suppression of EGFR signaling, deguelin inhibited anchorage-dependent, and independent growth of NSCLC cell lines, and significantly delayed tumorigenesis in vivo. "
11/01/2009 - "This perspective on Murillo et al. (beginning on page 942 in this issue of the journal) examines the potential of the naturally derived agent deguelin to prevent mammary tumorigenesis. "
11/16/2005 - "Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis."

10/01/2013 - "In this study we determined the effect of Deguelin on in vivo/vitro growth and metastasis of 4T1 cells. "
01/01/2022 - "However, the downstream mechanism of deguelin-suppressed metastasis of NSCLC cells is still not completely understood. "
10/01/2018 - "Deguelin would be a potential anti-metastasis agent against NSCLC."
10/01/2018 - "Our results demonstrate that deguelin inhibits NSCLC cell migration, invasion, and metastasis both in vitro and in vivo. "
01/01/2018 - "Thus, we selected those concentrations of deguelin for metastasis assay. "

06/01/2013 - "To study the inhibitory effect of Akt inhibitor deguelin on PC-3 human prostate cancer cell lines and its possible mechanism. "
12/15/2011 - "Taken together our study indicates that deguelin may have translational potential as therapeutic agent for advanced or metastatic prostate cancer."
12/15/2011 - "The aim of our study was to elucidate the effect of deguelin on the growth of prostate cancer cells and its putative mechanism of action. "
06/01/2013 - "Akt inhibitor deguelin can inhibit the proliferation of PC-3 human prostate cancer cells by affecting the down-stream signal molecules GSK3P3 and betaDM2 in the Akt pathway."
06/01/2013 - "PC-3 human prostate cancer cells were cultured in deguelin at the concentrations of 10, 100, 500 and 1 000 nmol/L for 24, 48 and 72 hours, respectively. "