glabridin

09/27/2022 - "In summary, glabridin can significantly potentiate the antiarthritic efficacy of MTX and can also minimize its hepatotoxicity via the inhibition of inflammation and oxidative stress. "
02/24/2023 - "Synthetic Glabridin Derivatives Inhibit LPS-Induced Inflammation via MAPKs and NF-κB Pathways in RAW264.7 Macrophages."
05/01/2020 - "Glabridin Alleviates Inflammation and Nociception in Rodents by Activating BKCa Channels and Reducing NO Levels."
12/01/1998 - "These data indicated that glabridin is a unique compound possessing more than one function; not only the inhibition of melanogenesis but also the inhibition of inflammation in the skins. "
12/01/1998 - "The inhibitory effect of glabridin from licorice extracts on melanogenesis and inflammation."

01/01/2021 - "Discovery and preclinical efficacy of HSG4112, a synthetic structural analog of glabridin, for the treatment of obesity."
01/01/2013 - "In this study, we investigated the anti-obesity effect of glabridin and glabridin-rich supercritical fluid extract of licorice (LSC). "
01/01/2023 - "has proposed HSG4112, a structural analogue of glabridin, as a novel anti-obesity compound. "
09/27/2022 - "Glabridin, a major bioalkaloid extracted from licorice root, improves metabolic abnormalities (i.e., obesity and diabetes) and protects against CVDs and neuronal disorders. "
01/01/2021 - "Our study demonstrates the key chemical components of glabridin pertinent to its weight loss effects and suggests HSG4112 as a promising novel drug candidate for the pharmacological treatment of obesity."

08/01/2019 - "Purposes: In the present study, we tried for the first time to examine the anti-proliferative and anti-apoptogenic effect of Glabridin (Glab) toward three groups of cancer cells (SKNMC, H1299, and A2780). "
01/01/2019 - "Therefore, objective of the present study was to examine the antibreast cancer effect of glabridin (GBN) and to evaluate its mechanism of action. "
09/01/2022 - "This work reports for the first time that glabridin could induce paraptosis-like cell death, which may give new therapeutic approaches for apoptosis-resistant breast cancers."
05/01/2016 - "In conclusion, glabridin is a potential multi-molecule-targeting inhibitor in the field of clinical prevention or treatment of cancer. "
05/01/2016 - "Several reports have demonstrated that glabridin could regulate multiple cellular signaling pathways to inhibit the progression of cancer. "

07/01/2012 - "In several obese rodent models, glabridin decreased body weight and adiposity with a concomitant reduction in fat cell size. "
01/01/2008 - "Treatment with glabridin significantly attenuated mortality, loss of body weight, shortening of the colon and severe clinical symptoms. "
06/01/2011 - "Glabridin treatment partially improved the reduced body weight and hyperglycemia of diabetic rats although the differences were not significant. "
01/01/2021 - "In high-fat diet (HFD)-induced obese male C57BL/6J mice, we tested the weight loss effect of synthetic compounds derived from a structure-activity relationship (SAR) study of glabridin, a natural compound known to reduce body weight and influence energy homeostasis. "
04/01/2013 - "The data obtained showed that glabridin significantly increased body weight, glucose tolerance and SOD activities in the liver, kidney and pancreas, while decreasing FBG levels and MDA content in the liver, kidney and pancreas. "

01/01/2019 - "Atherosclerosis is caused by various factors, and Glabridin may have protective effects on the cardiovascular system. "
01/01/2019 - "In conclusion, the results of the present study suggested that atherosclerosis may be associated with upregulated MLCK expression and activity, which was downregulated by Glabridin. "
05/14/1999 - "These phenomena could be responsible for the attenuation of atherosclerosis in E0 mice, induced by glabridin."
12/01/2015 - "The protective effect of glabridin on LDL oxidation, which is one of the important processes involved in the development of atherosclerosis, was demonstrated in vitro and in vivo and the mechanisms involved in this process were established well. "
01/01/2019 - "The purpose of the present study was to evaluate the effects of Glabridin on atherosclerosis and evaluate whether Glabridin attenuates arteriosclerosis and endothelial permeability by suppressing the myosin light chain (MLC) kinase (MLCK)/phosphorylated (p)-MLC system via the mitogen activated protein kinase (MAPK) signaling pathway. "