N-(4-hydroxyphenyl)arachidonylamide (AM404)

Also Known As:

AM404; 5,8,11,14-eicosatetraenamide, N-(4-hydroxyphenyl)-, (5Z,8Z,11Z,14Z)-; 5,8,11,14-eicosatetraenamide, N-(4-hydroxyphenyl)-, (all-Z)-; AM 404; AM-404; N-(4-hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide

Networked: 55 relevant articles (3 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - Eicosanoids: 3262
      - Arachidonic Acids: 122
        N-(4-hydroxyphenyl)arachidonylamide: 55
    - Essential Fatty Acids: 734
      - Arachidonic Acids: 122
        N-(4-hydroxyphenyl)arachidonylamide: 55

Experts

1.	Piomelli, D: 4 articles (03/2008 - 05/2000)
2.	Fowler, Christopher J: 4 articles (10/2006 - 04/2003)
3.	Fiebich, Bernd L: 3 articles (01/2021 - 01/2015)
4.	Makriyannis, Alexandros: 3 articles (01/2016 - 03/2003)
5.	Calignano, A: 3 articles (03/2008 - 05/2000)
6.	Di Marzo, Vincenzo: 3 articles (10/2006 - 03/2003)
7.	Eschalier, Alain: 2 articles (03/2021 - 09/2008)
8.	Mallet, Christophe: 2 articles (03/2021 - 09/2008)
9.	Muñoz, Eduardo: 2 articles (01/2021 - 01/2015)
10.	Saliba, Soraya Wilke: 2 articles (01/2021 - 01/2019)

Related Diseases

1.	Hyperalgesia 06/01/2021 - "AM404 attenuated mechanical and cold hyperalgesia with minimal effects on motor coordination. " 06/01/2021 - "The effects of intrathecal administration of AM404 on mechanical and cold hyperalgesia were examined using the electronic von Frey test and cold plate test, respectively. " 08/01/2006 - "Daily treatment with AM404 prevented, time- and dose-dependently, the development of thermal hyperalgesia and mechanical allodynia in neuropathic rats. " 11/01/2009 - "4. The results of the present study indicate that systemic administration of UCM707 and AM404 is effective in ameliorating chemical hyperalgesia in STZ-diabetic rats. " 11/01/2009 - "At 10 and 50 mg/kg, both UCM707 and AM404 reversed chemical hyperalgesia in diabetic rats. "
2.	Cognitive Dysfunction 02/01/2019 - "Chronic low dose of AM404 ameliorates the cognitive impairment and pathological features in hyperglycemic 3xTg-AD mice."
3.	Parkinsonian Disorders (Parkinsonism) 06/01/2004 - "Experimental parkinsonism alters anandamide precursor synthesis, and functional deficits are improved by AM404: a modulator of endocannabinoid function."
4.	Pain (Aches) 01/01/2023 - "AM404 is a potent activator of TRPV1, a major contributor to neuronal response to pain in the brain and dorsal horn. " 06/04/2007 - "AM404 decreases Fos-immunoreactivity in the spinal cord in a model of inflammatory pain." 11/01/2007 - "In the present study, we examined the effect of acute administration of the anandamide transport inhibitor AM404 in rat models of chronic neuropathic and inflammatory pain. " 10/01/2010 - "WIN55,212-2 and AM251 did not affect IA conditioning, while AM404 enhanced it, probably due to a drug-induced increase in pain sensitivity. " 11/01/2007 - "Actions of the endocannabinoid transport inhibitor AM404 in neuropathic and inflammatory pain models."
5.	Neuralgia (Stump Neuralgia) 06/01/2021 - "Here, we explored the effect of AM404 on neuropathic pain at the site of the spinal cord. " 01/31/2005 - "In this study we evaluated the effects of administrating N-(4-hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide (AM404), an inhibitor of anandamide reuptake and monitoring the expression of c-fos, a marker of activated neurons in an experimental model of neuropathic pain (sciatic nerve tying). " 06/01/2021 - "Inhibitory effect of intrathecally administered AM404, an endocannabinoid reuptake inhibitor, on neuropathic pain in a rat chronic constriction injury model." 08/01/2006 - "Thus, the effects of AM404, an inhibitor of anandamide uptake, were assessed in an experimental model of neuropathic pain in rats. " 03/01/2008 - "AM404, an anandamide transport inhibitor, reduces plasma extravasation in a model of neuropathic pain in rat: role for cannabinoid receptors."

Related Drugs and Biologics

1.	Endocannabinoids
2.	anandamide (arachidonylethanolamide)
3.	Formaldehyde (Formol)
4.	N- (3- furylmethyl)eicosa- 5,8,11,14- tetraenamide
5.	Streptozocin (Streptozotocin)
6.	Acetaminophen (Paracetamol)
7.	cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester (URB597)
8.	CB1 Cannabinoid Receptor (CB1 Receptor)
9.	Antipyretics
10.	Analgesics (Analgesic Drugs)

Related Therapies and Procedures

1.	Ligation
2.	Analgesia
3.	Ophthalmic Administration
4.	Therapeutics
5.	Injections