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phthalocyanine Pc 4

a photosensitizing agent

Networked: 10 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - phthalocyanine Pc 4: 10

Experts

1.	Separovic, Duska: 5 articles (07/2012 - 07/2005)
2.	Bielawski, Jacek: 4 articles (07/2012 - 01/2011)
3.	Pierce, Jason S: 4 articles (07/2012 - 01/2011)
4.	Breen, Paul: 3 articles (07/2012 - 06/2011)
5.	Joseph, Nicholas: 3 articles (07/2012 - 06/2011)
6.	Gudz, Tatyana I: 2 articles (07/2012 - 03/2012)
7.	VAN Buren, Eric: 2 articles (07/2012 - 03/2012)
8.	Bielawska, Alicja: 2 articles (06/2011 - 01/2011)
9.	Buren, Eric Van: 2 articles (06/2011 - 01/2011)
10.	Saad, Ziad H: 2 articles (06/2011 - 01/2011)

Related Diseases

1.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 07/01/2012 - "To explore the impact of CERS1 knockdown on apoptosis and the sphingolipid profile, post-PDT, with the silicone phthalocyanine Pc 4, in a human head and neck squamous carcinoma cell line. " 03/01/2012 - "To investigate the involvement of down-regulation of CerS6 in apoptosis and its impact on the sphingolipid profile post-PDT with the silicone phthalocyanine Pc 4 in a human head and neck squamous carcinoma cell line. " 06/10/2011 - "Treatment of SCCVII mouse squamous carcinoma cells using the silicone phthalocyanine Pc 4 for PDT induced increases in the prodeath global ceramides/dihydroceramides (DHceramides), and no changes in the prosurvival sphingosine-1-phosphate (S1P). " 01/01/2011 - "Using SCCVII mouse squamous carcinoma cells, and the silicone phthalocyanine Pc 4 for PDT, we showed that combining PDT with LCL30 (PDT/LCL30) was more effective than individual treatments in raising global ceramide levels, as well as in reducing dihydrosphingosine levels. "
2.	Photosensitivity Disorders (Photodermatitis) 09/01/2010 - "Photosensitization of intact heart mitochondria by the phthalocyanine Pc 4: Correlation of structural and functional deficits with cytochrome c release." 02/01/2001 - "Following photosensitization with the phthalocyanine Pc 4 and red light, cytochrome c was released from the mitochondria to equivalent extents in the two cell lines. " 07/01/2005 - "Since PDT with the photosensitizer phthalocyanine Pc 4 induces mitochondrial damage and the superoxide scavenger manganese superoxide dismutase (MnSOD) is localized to mitochondria, here we tested genetically the role of MnSOD in apoptosis and ceramide accumulation after photosensitization with Pc 4. Jurkat cells overexpressing wild-type MnSOD were protected from Pc 4-PDT-initiated apoptosis, but not from increased ceramide response to Pc 4-PDT. "
3.	Lymphoma (Lymphomas) 07/01/1997 - "Rapid tyrosine phosphorylation of HS1 in the response of mouse lymphoma L5178Y-R cells to photodynamic treatment sensitized by the phthalocyanine Pc 4." 03/01/1998 - "The ability of photodynamic treatment (PDT) with the phthalocyanine Pc 4 to activate cellular caspases has been assessed during the rapid apoptosis in murine lymphoma L5178Y-R cells. " 07/01/1997 - "The ability of photodynamic treatment (PDT) with the phthalocyanine Pc 4 to activate cellular signal transduction pathways in murine lymphoma L5178Y-R cells has been assessed by observing increases in protein tyrosine phosphorylation at early times post-PDT. "
4.	Neoplasms (Cancer) 01/01/2011 - "The phthalocyanine Pc 4 was developed initially for PDT of primary or metastatic cancers in the skin. "

Related Drugs and Biologics

1.	1-phenyl-3,3-dimethyltriazene (PDT)
2.	Silicones
3.	Ceramides
4.	Cytochromes c (Cytochrome c)
5.	Sphingolipids
6.	Caspases
7.	Photosensitizing Agents (Photosensitizers)
8.	Tyrosine (L-Tyrosine)
9.	Superoxide Dismutase
10.	Superoxides (Superoxide)