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tuberous sclerosis complex 1 protein (hamartin)

Subscribe to New Research on tuberous sclerosis complex 1 protein

a Tuberous Sclerosis Complex (TSC) gene product; MW 130 kDa; amino acid sequence in first source; GenBank AC002096 & AF013168

Also Known As:

hamartin; TSC1 protein, human; Tsc1 protein, mouse; Tsc1 protein, rat; hamartin protein, human; tuberous sclerosis 1 protein, human; tuberous sclerosis 1 protein, mouse; tuberous sclerosis 1 protein, rat

Networked: 122 relevant articles (4 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Neoplasm Proteins: 2
    - Tumor Suppressor Proteins: 254
      - tuberous sclerosis complex 1 protein: 122

Experts

1.	Hengstschläger, Markus: 5 articles (07/2009 - 12/2003)
2.	Rosner, Margit: 5 articles (07/2009 - 12/2003)
3.	Blenis, John: 5 articles (01/2006 - 10/2002)
4.	Gambello, Michael J: 4 articles (02/2015 - 09/2004)
5.	Kobayashi, Toshiyuki: 4 articles (01/2010 - 11/2002)
6.	Yamamoto, Yuji: 4 articles (01/2010 - 08/2002)
7.	Hino, Okio: 4 articles (01/2010 - 11/2002)
8.	Kotulska, Katarzyna: 4 articles (03/2009 - 02/2004)
9.	Jozwiak, Jaroslaw: 4 articles (02/2009 - 01/2005)
10.	Mizuguchi, Masashi: 4 articles (03/2007 - 01/2002)

Related Diseases

1.	Tuberous Sclerosis (Bourneville's Disease) 10/01/2015 - "We examined the potential benefit of gene therapy in a mouse model of tuberous sclerosis complex (TSC) in which there is embryonic loss of Tsc1 (hamartin) in brain neurons. " 10/01/2015 - "Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model." 08/01/2013 - "Tuberous sclerosis complex 1 (hamartin) is an effective endogenous neuroprotectant. " 03/01/2009 - "Dissociate expression of tuberous sclerosis complex 1 product hamartin in a skin and pulmonary lesion of a tuberous sclerosis complex." 11/01/2000 - "We have assessed the sensitivity and specificity of this method for analysis of the full coding sequence of the hamartin (TSC1) gene in 20 tuberous sclerosis patients, whose TSC1 genes previously had been studied by single strand conformation polymorphism analysis and protein truncation assay. "
2.	Epilepsy (Aura) 08/01/2013 - "Understanding the endogenous mechanism for neuroprotection mediated by hamartin may afford a novel approach to effective treatment of neurological diseases such as stroke, neurodegenerative diseases, and epilepsy, with possible applications to nonneurological conditions. " 01/01/2002 - "[A case of intractable epilepsy: diagnosis of tuberous sclerosis based on histopathological findings and immunohistochemical expression of hamartin and tuberin]." 09/01/2011 - "Recently, understanding the neurobiology of hamartin and tuberin in the development of epilepsy and cognitive impairment associated with tuberous sclerosis complex allowed the development of sirolimus and everolimus to be used in human clinical trials. "
3.	Neoplasm Metastasis (Metastasis) 07/01/2005 - "Likewise, hamartin levels were significantly lower in patients with metastasis, recurrence and mortality, when compared with those remained disease free (P = 0.001, 0.041 and 0.003, respectively). " 12/01/2003 - "Hamartin and tuberin may play functional roles in the suppression of cell migration and/or metastasis, possibly through their regulation of the small GTPase Rho."
4.	Stroke (Strokes) 08/01/2013 - "Understanding the endogenous mechanism for neuroprotection mediated by hamartin may afford a novel approach to effective treatment of neurological diseases such as stroke, neurodegenerative diseases, and epilepsy, with possible applications to nonneurological conditions. "
5.	Neurodegenerative Diseases (Neurodegenerative Disease) 08/01/2013 - "Understanding the endogenous mechanism for neuroprotection mediated by hamartin may afford a novel approach to effective treatment of neurological diseases such as stroke, neurodegenerative diseases, and epilepsy, with possible applications to nonneurological conditions. "

Related Drugs and Biologics

1.	tuberous sclerosis complex 2 protein (tuberin)
2.	Proteins (Proteins, Gene)
3.	Carbon Monoxide
4.	Sirolimus (Rapamycin)
5.	Staphylococcal Protein A (A, Protein)
6.	AMP-Activated Protein Kinases
7.	Insulin (Novolin)
8.	Biological Markers (Surrogate Marker)
9.	Protein Kinases (Protein Kinase)
10.	everolimus