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1- propyl- 5- (3- p- tolylisoxazol- 5- yl)- 1,2,3,6- tetrahydropyridine

sigma(1) receptor antagonist; structure in first source

Also Known As:

PD 144418; PD-144418; PD144418

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Isoxazoles: 155
      - 1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine: 1
  - Pyridines: 88
    - 1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine: 1

Related Diseases

1.	Neuroblastoma 01/01/1997 - "For sigma (sigma 1 and sigma 2 respectively) sites, PD 144418 affinities were determined using whole guinea pig brain membranes with [3H](+)-pentazocine and neuroblastoma x glioma cell membranes using [3H]1,3,di-O-tolylguanidine (DTG) in the presence of 200 nM (+)-pentazocine. "
2.	Glioma (Gliomas) 01/01/1997 - "For sigma (sigma 1 and sigma 2 respectively) sites, PD 144418 affinities were determined using whole guinea pig brain membranes with [3H](+)-pentazocine and neuroblastoma x glioma cell membranes using [3H]1,3,di-O-tolylguanidine (DTG) in the presence of 200 nM (+)-pentazocine. "

Related Drugs and Biologics

1.	Pentazocine (Talwin)