lysenin

06/01/2012 - "In the present study, we screened for inhibitors of lysenin-induced hemolysis by using an optimized screening system and found a methanolic extract of Dalbergia latifolia leaves to be a potential candidate. "
05/18/2021 - "In contrast, PEGylation reduced the effectiveness against lysenin-induced hemolysis and altered binding dynamics. "
06/01/2012 - "Although the mechanism of lysenin-induced hemolysis is unique, its precise mechanism of action and its inhibitors are poorly understood. "
08/03/2004 - "LRP-2 specifically bound SM and induced hemolysis like lysenin. "
01/01/2004 - "After binding to the cell membranes of target cells, lysenin forms oligomers in an SM-dependent manner, with subsequent formation of pores with a hydrodynamic diameter of approximately 3?nm. The biochemical interactions between lysenin and SM in cell membranes are responsible for the pharmacological activities of lysenin and of CF that contains lysenin in vertebrates, such as hemolysis, cytotoxicity, and contraction of smooth muscle in vitro and vasodepressor activity and lethality in vivo. "

02/27/1998 - "Immunofluorescence staining of fibroblasts derived from a patient with Niemann-Pick disease type A showed that lysenin stained the surfaces of the fibroblasts uniformly, whereas intense lysosomal staining was observed when the cells were permeabilized by digitonin treatment. "

02/27/2021 - "Regenerating earthworms have decreased pattern recognition receptors (PRRs) (e.g., TLR, except for scavenger receptor) and antimicrobial peptides (AMPs) (e.g., lysenin) mRNA patterns compared to intact earthworms. "

01/01/2004 - "The inhibitory role of glycolipids in the binding of lysenin to SM was confirmed by comparing the glycolipid-deficient mutant melanoma cell line with its parent cell. "