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platelet glycoprotein (GP)IIIa 49-66
Also Known As:
GPIIIa (49-66); GPIIIa-(49-66)
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Glycoproteins: 24834
Membrane Glycoproteins: 2252
Platelet Membrane Glycoproteins: 1214
Platelet Glycoprotein GPIIb-IIIa Complex: 182
platelet glycoprotein (GP)IIIa 49-66: 2
Membrane Proteins: 10078
Membrane Glycoproteins: 2252
Platelet Membrane Glycoproteins: 1214
Platelet Glycoprotein GPIIb-IIIa Complex: 182
platelet glycoprotein (GP)IIIa 49-66: 2
Cell Surface Receptors: 2125
Immunologic Receptors: 9
Integrins: 14304
Cytoadhesin Receptors
Platelet Glycoprotein GPIIb-IIIa Complex: 182
platelet glycoprotein (GP)IIIa 49-66: 2
Platelet Membrane Glycoproteins: 1214
Platelet Glycoprotein GPIIb-IIIa Complex: 182
platelet glycoprotein (GP)IIIa 49-66: 2
Peptides: 82426
Peptide Fragments: 373
platelet glycoprotein (GP)IIIa 49-66: 2
Carbohydrates: 22023
Glycoconjugates: 1353
Glycoproteins: 24834
Membrane Glycoproteins: 2252
Platelet Membrane Glycoproteins: 1214
Platelet Glycoprotein GPIIb-IIIa Complex: 182
platelet glycoprotein (GP)IIIa 49-66: 2
Experts
1.
Karpatkin, S
: 1 article (06/2000)
2.
Nardi, M
: 1 article (06/2000)
Related Diseases
1.
Thrombocytopenia (Thrombopenia)
07/08/1997 - "
Thus HIV-1-ITP patients have high-affinity anti-platelet GPIIIa against a major antigenic determinant, GPIIIa-(49-66), which correlates inversely with platelet count and induces thrombocytopenia in mice.
"
07/08/1997 - "
GPIIIa-(49-66) is a major pathophysiologically relevant antigenic determinant for anti-platelet GPIIIa of HIV-1-related immunologic thrombocytopenia.
"
07/08/1997 - "
Affinity-purified antibody, 25-50 microg given i.p., resulted in a precipitous drop in platelet count to 30% of baseline, with nadir at 4 hr and return to normal in 36 hr. No effect was noted with control IgG. Acute thrombocytopenia could be prevented or reversed by the injection of the GPIIIa-(49-66) albumin conjugate at zero time or 2 hr after antibody, respectively, but not with a scrambled peptide-albumin conjugate.
"
06/19/2000 - "
To test the in vivo effectiveness of the IgM antiidiotype, thrombocytopenia was induced in mice with 25 microgram of affinity-purified anti-GPIIIa 49-66 (mouse GPIIIa has 83% homology with human GPIIIa and Fc receptors for human IgG1).
"
Related Drugs and Biologics
1.
Integrin beta3 (GPIIIa)
2.
Immunoglobulin G (IgG)
3.
Fc Receptors (Fc Receptor)
4.
Peptides (Polypeptides)
5.
Immunoglobulin M (IgM)
6.
Epitopes
7.
Albumins