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FRZB protein

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inhibits Wnt activity; related to frizzled proteins; RefSeq NM_001463 (human); NM_011356 (mouse); XM_215757 (rat)

Also Known As:

FRZB protein, bovine; FRZB protein, human; Fritz protein, human; Frzb protein, mouse; Frzb protein, rat; HFIZ protein, human; Mfiz protein, mouse; SFRP3 protein, human; Sfrp-1 protein; Sfrp3 protein, mouse; frezzled (fre) protein; frezzled protein; frezzled protein, mouse; fritz protein; fritz protein, Xenopus; fritz protein, mouse; frizzled-related protein; frizzled-related protein, Bos taurus; frizzled-related protein, human; frizzled-related protein, mouse; frizzled-related protein, rat; frzb-1 protein, mouse

Networked: 228 relevant articles (2 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hartmann, Arndt: 4 articles (10/2015 - 04/2004)
2.	Shimono, Akihiko: 4 articles (08/2015 - 07/2010)
3.	Hirata, Hiroshi: 4 articles (06/2010 - 08/2008)
4.	Dahiya, Rajvir: 4 articles (06/2010 - 08/2008)
5.	Chang, Ching-Jin: 4 articles (11/2006 - 05/2003)
6.	Lee, Jia-Lin: 4 articles (11/2006 - 05/2003)
7.	Lin, Chung-Tien: 4 articles (11/2006 - 05/2003)
8.	Stoehr, Robert: 3 articles (10/2015 - 04/2004)
9.	Arfuso, Frank: 3 articles (01/2015 - 01/2012)
10.	Wang, Rui: 3 articles (12/2014 - 01/2011)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/2012 - "We showed here that Wnt5a activated Dvl2, Daam1 and RhoA, and promoted migration of breast cancer cells, which was, however, abolished by Secreted Frizzled-related protein 2 (sFRP2) pretreatment. " 01/01/2011 - "Secreted frizzled-related protein 1 (SFRP1) antagonizes this pathway and loss of SFRP1 expression is frequently observed in breast tumors and breast cancer cell lines. " 01/01/2009 - "Moreover, many breast tumors show hypermethylation of the secreted Frizzled-related protein 1 (sFRP1) promoter region, causing low expression of this WNT antagonist. " 01/01/2007 - "Most breast tumors show hypermethylation of the promoter region of secreted Frizzled-related protein 1 (sFRP1), a negative WNT pathway regulator, leading to downregulation of its expression. " 06/08/2006 - "The gene for secreted frizzled-related protein 1 (SFRP1) encodes a soluble Wnt antagonist and is located in a chromosomal region (8p22-p12) that is often deleted in breast cancer. "
2.	Fibrosis (Cirrhosis) 11/07/2014 - "Secreted Frizzled-related protein 1 (Sfrp1) regulates the progression of renal fibrosis in a mouse model of obstructive nephropathy." 03/15/2014 - "The failing hamster heart exhibits marked fibrosis and increased expression of secreted Frizzled-related protein 2 (sFRP2) amenable to reversal by mesenchymal stem cell (MSC) therapy. " 11/01/2010 - "Secreted frizzled related protein 4 reduces fibrosis scar size and ameliorates cardiac function after ischemic injury." 12/07/2010 - "Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction." 01/01/2014 - "Here, we studied the role of two extracellular Wnt antagonists, secreted frizzled-related protein-1 (SFRP1) and frizzled-related protein (FRZB) on lung fibrosis in vitro and in vivo. "
3.	Cicatrix (Scar) 11/01/2010 - "Secreted frizzled related protein 4 reduces fibrosis scar size and ameliorates cardiac function after ischemic injury."
4.	Neoplasms (Cancer) 05/01/2008 - "Previous in vitro studies identified secreted frizzled related protein 1 (SFRP1) as a candidate pro-proliferative signal during prostatic development and cancer progression. " 11/01/2015 - "Deregulation of secreted frizzled-related protein 2 (sFRP2) has been found in many types of cancer. " 07/01/2015 - "Deregulation of secreted frizzled-related protein 1 (SFRP1) has been found in many types of cancer. " 01/01/2015 - "Secreted frizzled-related protein 4 and its implications in cancer and apoptosis." 01/01/2014 - "Secreted frizzled related protein 1 (SFRP1) functions as an important inhibitor of the Wnt pathway and is a known tumor suppressor gene, which is epigenetically silenced in a variety of tumors e.g. "
5.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2011 - "The aim of this study was to investigate the diagnostic and prognostic significance of the methylation status of secreted frizzled-related protein 2 (SFRP2) in colorectal cancer (CRC). " 03/15/2012 - "The combination of oligoamines and DFMO results in a synergistic re-expression of aberrantly silenced tumour-suppressor genes, including SFRP2 (secreted frizzled-related protein 2), which encodes a Wnt signalling pathway antagonist and plays an anti-tumorigenic role in colorectal cancer. " 05/01/2011 - "The Dickkopf-1 (DKK1) and Secreted Frizzled Related Protein 1 (SFRP1) genes encode extracellular inhibitors of Wnt signaling that are frequently silenced by promoter hypermethylation in colorectal cancer (CRC). " 01/01/2011 - "Diagnostic and prognostic value of the methylation status of secreted frizzled-related protein 2 in colorectal cancer." 11/01/2007 - "[Hypermethylation and regulation of expression of secreted frizzled-related protein genes in colorectal tumor]."

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