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SDZ 280.636

a synthetic muramyl dipeptide derivative; structure given in first source

Also Known As:

3-O-(N-acetylmuramyl-L-threonyl-D-isoglutamyl)1,2-di-O-palmitoyl-sn-glycerol; SDZ-280.636

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Dipeptides: 945
      - SDZ 280.636: 1

Related Diseases

1.	Allergic Rhinitis 01/01/1998 - "Our data suggest that SDZ 280.636 may be useful in the therapeutic and prophylactic management of human atopic disease such as allergic rhinitis, asthma, and other atopic diseases."
2.	Immediate Hypersensitivity 01/01/1998 - "V. Oral administration of a synthetic derivative of the inner bacterial cell wall (SDZ 280.636) to sensitized mice induces isotype specific suppression of peak hapten specific IgE antibody forming cell responses, serum IgE levels and immediate hypersensitivity responses." 01/01/1998 - "SDZ 280.636, a nontoxic diacyl glycerol derivative of muramyl dipeptide (MDP), a component of the inner bacterial cell wall, which is suitable for use in man, suppressed hapten specific IgE antibody forming cell (AFC) responses in spleen, serum levels of hapten specific IgE and hapten specific immediate hypersensitivity (i.h.) responses in skin, when fed to mice at the peak of a hapten specific IgE AFC response. "
3.	Asthma (Bronchial Asthma) 01/01/1998 - "Our data suggest that SDZ 280.636 may be useful in the therapeutic and prophylactic management of human atopic disease such as allergic rhinitis, asthma, and other atopic diseases."

Related Drugs and Biologics

1.	Immunoglobulin E (IgE)
2.	Haptens
3.	Glycerol (Glycerine)
4.	Acetylmuramyl-Alanyl-Isoglutamine

Related Therapies and Procedures

1.	Oral Administration