PF 1092A
eremophilane type sesquiterpene; progesterone receptor ligand isolated from Penicillium oblatum; structure in first source
Also Known As:
PF-1092A; PF1092A; (4aR,5R,6R,7S)-6-acetoxy-7-hydroxy-4a,5,6,7-tetrahydro-3,4a,5-trimethylnaphtho(2,3-b)furan-2(4H)-one
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Bio-Agent Context: Research Results
Experts
Related Diseases
1. | Breast Neoplasms (Breast Cancer)
11/02/2001
- " PF1092A ((4aR,5R,6R,7S)-6-acetoxy-7-hydroxy-4a,5,6,7-tetrahydro-3,4a,5-trimethylnaphtho[2,3-b]furan-2(4H)-one) showed good and moderate affinity for porcine and human progesterone receptors in in vitro receptor binding assays, respectively, and partial agonist activity for the progesterone receptor, as determined in assays of two types of progesterone-dependent enzymes in human mammary carcinoma T47D cells. "
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