abacavir (Ziagen)

a carbocyclic nucleoside with potent selective anti-HIV activity

Also Known As:

Ziagen; 1592U89; ((1R,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-cyclopent-2-enyl)methanol; ((1R,4S)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-enyl)methanol; (+)-abacavir; (+)-abacavir sulfate; (+-)-abacavir sulfate; (-)-cis-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-2-cyclopentene-1-methanol; (1R,4R)-abacavir; (1R,4S)-abacavir sulfate; (1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-2-cyclopentene-1-methanol; (1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-2-cyclopentene-1-methanol succinate (1:1) (salt); 2-cyclopentene-1-methanol, 4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-, (1R,4S)-, sulfate (2:1); 2-cyclopentene-1-methanol, 4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-, (1S,4R)-, rel-, sulfate (2:1); 2-cyclopentene-1-methanol, 4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-, hydrochloride, hydrate (1:1:1), (1S,4R)-; Abamune; DRG 0257; DRG-0257; DRG0257; abacavir enantiomer; abacavir hydrochloride monohydrate; abacavir succinate; abacavir sulfate; abacavir sulfate racemic; abacavir sulfate, (+)-; abacavir sulfate, (+-)-; abacavir sulfate, (1R,4S)-; abacavir sulphate; abacavir, (+)-; abacavir, (1R,4S)-; abacavir, trans-; abacavir, trans-, (+-)-; avacavir; trans-abacavir; trans-abacavir R,R-

Networked: 767 relevant articles (28 outcomes, 129 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Mallal, Simon: 21 articles (01/2015 - 05/2003)
2.	Phillips, Elizabeth J: 20 articles (01/2022 - 11/2002)
3.	Pirmohamed, Munir: 17 articles (01/2020 - 05/2003)
4.	Phillips, Elizabeth: 16 articles (01/2015 - 03/2004)
5.	Nolan, David: 15 articles (06/2020 - 01/2003)
6.	Mallal, Simon A: 9 articles (01/2022 - 06/2005)
7.	Reiss, Peter: 9 articles (10/2021 - 07/2004)
8.	Purcell, Anthony W: 9 articles (01/2021 - 03/2004)
9.	Domingo, Pere: 9 articles (12/2016 - 06/2002)
10.	McCluskey, James: 8 articles (01/2021 - 03/2004)

Related Diseases

1.	Hypersensitivity (Allergy) 10/01/2010 - "Abacavir (ABC) is an antiretroviral drug highly effective in the treatment of HIV, but its intake can cause severe hypersensitivity reaction (HSR). " 03/01/2015 - "Screening for HLA-B5701 to avoid abacavir hypersensitivity reactions has become a routine part of clinical care, and has markedly improved drug safety. " 05/01/2006 - "The strong association between HLA-B5701 and abacavir hypersensitivity reaction shows promise for a genetic screening test to be feasibly incorporated into clinical practice. " 04/01/2010 - "Recent success in developing clinically useful genetic tests that have allowed us to predict the risk of abacavir-induced hypersensitivity has helped to pave the path for a pharmacogenetic approach. " 10/01/2022 - "Abacavir hypersensitivity reaction was reported in nine (38%) studies, with an incidence ranging from 0·00% to 8·26% (I2=85%; p<0·0001). "
2.	Infections 12/01/2016 - "Effectiveness and safety of an abacavir/lamivudine + rilpivirine regimen for the treatment of HIV-1 infection in naive patients." 01/01/2015 - "The use of abacavir has been linked with increased cardiovascular risk in patients with human immunodeficiency virus infection; however, the mechanism involved remains unclear. " 12/01/2006 - "Abacavir/lamividune combination in the treatment of HIV-1 infection: a review." 03/01/2004 - "Abacavir is an effective antiretroviral drug used to treat HIV-1 infection. " 11/08/2022 - "Severe abacavir hypersensitivity reaction in a patient with human immunodeficiency virus infection: a case report."
3.	Weight Gain 10/20/2021 - "Switch from abacavir to TAF was associated with less weight gain than switch from TDF to TAF and was not associated with increased risk for ≥10% weight gain. " 06/01/2009 - "In multivariate analysis, substitution with tenofovir/abacavir remained significantly associated with weight gain. " 01/01/2023 - "Tenofovir alafenamide was also associated with higher weight gain than tenofovir disoproxil or abacavir. " 06/01/2022 - "For backbones, TAF led to higher weight gain relative to tenofovir disoproxil fumarate (TDF), abacavir, and zidovudine. " 06/01/2009 - "This is the first study in Africa assessing weight gain as a proxy for recovery after stavudine substitution due to lipoatrophy, providing supporting evidence that tenofovir/abacavir is superior to zidovudine. "
4.	Acquired Immunodeficiency Syndrome (AIDS) 02/28/2006 - "The Pediatric AIDS Clinical Trials Group P1026s study is an on-going, prospective, non-blinded pharmacokinetic study of pregnant women receiving one or more antiretroviral drugs for routine clinical care, including a cohort receiving abacavir 300 mg twice daily. " 07/01/2019 - "A total of 192 patients who received abacavir were identified, most male (67.1%), black or racially mixed (77.8%), and having diagnosis of a previous AIDS defining conditions (83.7%). " 01/01/2019 - "In ART-naïve, a concomitant AIDS diagnosis predicted the risk of discontinuing DTG for any reason (adjusted relative hazard (aRH) = 3.38, p = 0.001), whereas starting DTG in combination with abacavir (ABC) was associated with a higher risk of discontinuing because of toxicity (aRH = 3.30, p = 0.009). " 01/01/2019 - "Abacavir is an antiretroviral drug used to reduce human immunodeficiency virus (HIV) replication and decrease the risk of developing acquired immune deficiency syndrome (AIDS). " 08/01/2016 - "Abacavir is currently recommended as a part of first line regimen by National AIDS Control Organization. "
5.	HIV Infections (HIV Infection) 09/01/2001 - "The results of this animal study indicate that abacavir would be a useful addition to a treatment regimen against HIV-infection within the brain." 11/10/2023 - "HIV infection and abacavir-containing antiretroviral regimens are associated with vascular endothelial dysfunction and increased cardiovascular risk. " 11/01/2012 - "In multivariable analysis, older age, longer duration of HIV infection, and current abacavir use were associated with lower FMD. " 04/01/2012 - "Abacavir is used to treat HIV infection in both adults and children. " 07/15/2011 - "The application of this methodology is a rapid and simple method to detect the HCP5 polymorphism (rs2395029) previous to administration of Abacavir in patients with HIV infection."

Related Drugs and Biologics

1.	Lamivudine (Epivir)
2.	HLA-B Antigens (HLA-B)
3.	Nucleosides
4.	Tenofovir (Viread)
5.	abacavir (Ziagen)
6.	Reverse Transcriptase Inhibitors
7.	HLA-B57 antigen
8.	Zidovudine (Retrovir)
9.	efavirenz (Sustiva)
10.	Stavudine (Zerit)

Related Therapies and Procedures

1.	Therapeutics
2.	Highly Active Antiretroviral Therapy (HAART)
3.	Art Therapy
4.	Precision Medicine
5.	Stents