N-acetylglucosaminyltransferase IGnT

catalyzes conversion of i antigen to I antigen; 87% identical to human enzyme; isolated from mouse; amino acid sequence in first source; GenBank U68182

Also Known As:

GCNT2 protein, mouse; I-branching enzyme; IGnT enzyme; Ibeta6-N-acetylglucosaminyltransferase; beta-1,3-N-acetylglucosaminyltransferase I, mouse; beta3GnT1, mouse

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Glycosyltransferases: 784
      - N-Acetylhexosaminyltransferases
        N-Acetylglucosaminyltransferases: 23
        N-acetylglucosaminyltransferase IGnT: 3

Experts

1.	Dimitroff, Charles J: 1 article (01/2019)
2.	Chen, Wei: 1 article (07/2011)
3.	Kreike, Bas: 1 article (07/2011)
4.	Meng, Fanyan: 1 article (07/2011)
5.	Miller, Fred R: 1 article (07/2011)
6.	Sethi, Seema: 1 article (07/2011)
7.	Wu, Guojun: 1 article (07/2011)
8.	Wu, Sherwin: 1 article (07/2011)
9.	Zhang, Haijun: 1 article (07/2011)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 07/15/2011 - "In this study, we have showed that GCNT2, a gene-encoding glucosaminyl (N-acetyl) transferase 2, I-branching enzyme, is overexpressed in highly metastatic breast cancer cell lines of human and mouse origin and basal-like breast tumor samples. "
2.	Tics (Tic) 01/01/2023 - "MM cells, including TICs, express a unique glycome featuring i-linear poly-N-acetyllactosamines through the loss of I-branching enzyme, β1,6 N-acetylglucosaminyltransferase 2. Whether hypoxia instructs MM TIC development by modulating the glycome signature remains unknown. "
3.	Neoplasms (Cancer) 01/01/2019 - "I-branched glycans catalyzed principally by the I-branching enzyme GCNT2 are now indicated in several malignancies. "
4.	Hypoxia (Hypoxemia) 01/01/2023 - "MM cells, including TICs, express a unique glycome featuring i-linear poly-N-acetyllactosamines through the loss of I-branching enzyme, β1,6 N-acetylglucosaminyltransferase 2. Whether hypoxia instructs MM TIC development by modulating the glycome signature remains unknown. "

Related Drugs and Biologics

1.	Transferases
2.	Polysaccharides (Glycans)
3.	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase (N-acetylglucosaminyltransferase)