flumioxazin

Also Known As:

7-fluoro-6-((3,4,5,6-tetrahydro)phthalimido)-4-(2-propynyl)-1,4-benzoxazin-3(2 H)-one; S 53482; S-53482; 1H-Isoindole-1,3(2H)-dione, 2-(7-fluoro-3,4-dihydro-3-oxo-4-(2-propyn-1-yl)-2H-1,4-benzoxazin-6-yl)-4,5,6,7-tetrahydro-

Networked: 6 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Otani, Mitsuhiro: 3 articles (01/2022 - 01/2021)
2.	Abe, Jun: 2 articles (01/2022 - 01/2021)
3.	Asano, Koji: 2 articles (01/2022 - 01/2022)
4.	Ihara, Ryo: 2 articles (01/2022 - 01/2021)
5.	Miyamoto, Taiki: 2 articles (01/2022 - 01/2021)
6.	Fantel, Alan G: 2 articles (01/2021 - 04/2014)
7.	Kawamura, Satoshi: 2 articles (01/2021 - 04/2014)
8.	Barlow, Susan: 1 article (01/2022)
9.	Fukuda, Takako: 1 article (01/2022)
10.	Hosokawa, Yoshinori: 1 article (01/2022)

Related Diseases

1.	Ventricular Heart Septal Defects (Ventricular Septal Defect) 12/01/2023 - "Current evidence suggests that flumioxazin could induce cardiac defects (ventricular septal defects) in vertebrates, but the underlining mechanisms remain unclear. " 01/01/2022 - "Flumioxazin induces anemia and developmental toxicity in rats, including ventricular septal defect and embryofetal death. " 04/01/2014 - "S-53482 and S-23121 are N-phenylimide herbicides and produced embryolethality, teratogenicity (mainly ventricular septal defects and wavy ribs), and growth retardation in rats in conventional oral developmental toxicity studies. " 01/01/2021 - "Rat developmental toxicity including embryolethality and teratogenicity (mainly ventricular septal defects and wavy ribs) were produced by S-53482, an N-phenylimide herbicide that inhibits protoporphyrinogen oxidase (PPO) common to chlorophyll and heme biosynthesis. " 11/01/1996 - "An N-phenylimide herbicide, S-53482, inhibits protoporphyrinogen oxidase, an enzyme common to chlorophyll and heme biosynthesis, and produces embryolethality, teratogenicity [mainly ventricular septal defects (VSD) and wavy ribs], and growth retardation in rats. "
2.	Anemia 01/01/2022 - "Flumioxazin induces anemia and developmental toxicity in rats, including ventricular septal defect and embryofetal death. " 01/01/2022 - "In this study, as a final weight-of-evidence approach for assessing the human safety of flumioxazin, we compared the toxic potential of inhibition of heme synthesis leading to anemia between human and rat embryonic erythroid cells, which were degenerated as the target of flumioxazin in the rat developmental toxicity. " 01/01/2022 - "Derived human and rat embryonic erythroid cells were treated with flumioxazin or dihydroartemisinin (DHA), an anti-malarial drug that causes reduction of embryonic erythroid cells and leads to anemia without species differences. " 01/01/2022 - "Fetal rat anemia from flumioxazin, an N-phenylimide herbicide, is caused by suppression of heme synthesis resulting from inhibition of protoporphyrinogen oxidase (PPO). "
3.	Acute Erythroblastic Leukemia (Erythroleukemia) 01/01/2022 - "In vitro studies using several types of rat and human cells (erythroblasts derived from erythroleukemia cell lines, cord blood, or pluripotent stem cells), showed that flumioxazin decreased heme synthesis in rat cells but not in human cells, demonstrating a clear, qualitative species difference. "
4.	Cardiotoxicity 12/01/2023 - "The results suggest that excessive ROS production, which could be mediated through AhR, led to apoptosis, contributing to the cardiotoxicity of flumioxazin in zebrafish embryos. " 12/01/2023 - "Oxidative stress contributes to flumioxazin-induced cardiotoxicity in zebrafish embryos." 12/01/2023 - "To verify whether oxidative stress plays an important role in flumioxazin-induced cardiotoxicity, we compared the differences in heart phenotype, oxidative stress level, apoptosis, and gene expression between flumioxazin exposure and a normal environment, and we also tested whether cardiotoxicity could be rescued with astaxanthin. " 12/01/2023 - "Because of the inhibitory effect of flumioxazin on polyphenol oxidase, the assumption is made that flumioxazin-induced cardiotoxicity is caused by oxidative stress. "

Related Drugs and Biologics

1.	Heme (Haem)
2.	Herbicides
3.	S 23121
4.	Protoporphyrinogen Oxidase (Protox)
5.	Chlorophyll
6.	Enzymes
7.	Catechol Oxidase (Diphenol Oxidase)
8.	Antimalarials (Antimalarial Agents)
9.	artenimol (dihydroartemisinin)
10.	astaxanthine (astaxanthin)