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tecastemizole

Also Known As:

1-((4-flurophenyl)methyl)-N-4-piperidinyl-1H-benzimidazol-2-amine; norastemizole; norastemizole hydrobromide

Networked: 6 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - tecastemizole: 6
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - tecastemizole: 6

Experts

1.	Hefni, A: 1 article (06/2007)
2.	Lever, R: 1 article (06/2007)
3.	Moffatt, J D: 1 article (06/2007)
4.	Page, C P: 1 article (06/2007)
5.	Paul, W: 1 article (06/2007)
6.	Paakkari, Ilari: 1 article (02/2002)
7.	Salmun, Luis M: 1 article (02/2002)
8.	Lockey, R F: 1 article (12/2000)
9.	Reichmuth, D: 1 article (12/2000)
10.	Bachmann, K A: 1 article (10/2000)

Related Diseases

1.	Seasonal Allergic Rhinitis (Hay Fever) 12/01/2000 - "Desloratadine and norastemizole, metabolites of loratadine and astemizole, respectively, are 2 other second generation antihistamines found to be effective treatments for seasonal allergic rhinitis. "
2.	Leukemia 03/12/1997 - "To study the mechanism of this inhibition, we investigated the effects of astemizole and one of its active metabolites, norastemizole, on different phases of Fc epsilon RI (the high affinity receptor for the immunoglobulin IgE) receptor-activated signal transduction in rat basophilic leukemia cells (RBL-2H3), leading to exocytosis. "
3.	Cardiotoxicity 10/01/2000 - "Following a single dose of norastemizole (25 mg p.o.), there is significant attenuation of histamine-induced wheal and flare responses within 30 min. The drug's major advantage is its lack of cardiotoxicity or interactions with other drugs that increase the risk of developing serious arrhythmias [301469]. " 02/28/2002 - "Active hydrophilic metabolites of the second-generation antihistaminic compounds (ebastine-carebastine, loratadine-desloratadine, terfenadine-fexofenadine, astemizole-norastemizole) are new compounds with probably reduced risk for drug interactions and cardiac toxicity."
4.	Hypersensitivity (Allergy) 10/01/2000 - "Sepracor and Janssen are developing the histamine H1 antagonist, norastemizole (an active metabolite of Johnson & Johnson's Hismanal), for the potential, non-sedating treatment of allergy. " 02/01/2002 - "The broad anti-inflammatory properties of desloratadine and mizolastine, which distinguish these agents from other H(1) antagonists in clinical development (e.g., norastemizole and levocetirizine), suggest they may have a more profound impact on the underlying disease in patients suffering from different forms of allergy. "
5.	Pneumonia (Pneumonitis) 06/01/2007 - "Effects of tecastemizole were assessed in a murine model of allergic lung inflammation, in passive cutaneous anaphylaxis (PCA) responses in guinea-pig skin and in in vitro assays measuring endothelial adhesion molecule expression and leucocyte-endothelial adhesion. "

Related Drugs and Biologics

1.	Astemizole
2.	desloratadine (Aerius)
3.	Loratadine (Alavert)
4.	Non-Sedating Histamine H1 Antagonists (Histamine H1 Antagonists, Non Sedating)
5.	IgE Receptors (Fc epsilon RI)
6.	Immunoglobulins (Immunoglobulin)
7.	Terfenadine (Seldane)
8.	Liposomes (Liposome)
9.	Histamine H1 Antagonists
10.	Histamine (Histamine Dihydrochloride)