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T 794

reversibly inhibits monoamine oxidase A; structure in first source

Also Known As:

3-(6-(cyclopropylmethoxy)-2-naphthalenyl)-5-(methoxymethyl)-2-oxazolidone; T-794

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        T 794: 3
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - T 794: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - Oxazolidinones: 316
        T 794: 3

Experts

1.	Gotay, Carolyn C: 1 article (11/2007)
2.	Pagano, Ian S: 1 article (11/2007)
3.	Ransom, Sean: 1 article (11/2007)

Related Diseases

1.	Stroke (Strokes) 04/01/1997 - "The results suggest that T-794 may make an important contribution to the treatment of emotional disturbances following stroke." 04/01/1997 - "Possible therapeutic effect of T-794, a novel reversible inhibitor of monoamine oxidase-A, on post-stroke emotional disturbances, assessed in animal models of depression."
2.	Tremor (Tremors) 03/01/1998 - "Unlike tricyclic antidepressants, T-794 did not prevent the oxotremorine-induced tremor even at 100 mg/kg p.o.; in this it demonstrated a lack of the anticholinergic activity. "
3.	Neoplasms (Cancer) 11/01/2007 - "Survivors of multiple primary cancer diagnoses had significantly lower global QOL (t (792) = 5.42; P < .001), vitality (Student t test [t] (794) = 2.41; P < .01), and existential well-being (t (775) = 2.78; P < .01), and higher intrusive stress symptoms (t (775) = -1.93; P < .05). "
4.	Ischemia 04/01/1997 - "Effect of T-794 was also examined in the behavioral despair test in rats subjected to forebrain ischemia. "
5.	Hypothermia 04/01/1997 - "Oral administration of T-794 potently prevented reserpine-induced ptosis (ED50 = 4.41 mg/kg), akinesia (ED50 = 3.29 mg/kg), and hypothermia (minimum effective dose = 3 mg/kg) in mice. "

Related Drugs and Biologics

1.	Antidepressive Agents (Antidepressants)
2.	Therapeutic Uses
3.	Oxazolidinones (2 Oxazolidone)
4.	Cholinergic Antagonists (Anticholinergics)
5.	Reserpine (Serpasil)
6.	Oxotremorine
7.	Monoamine Oxidase Inhibitors (Monoamine Oxidase Inhibitor)
8.	Monoamine Oxidase (MAO)
9.	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)

Related Therapies and Procedures

1.	Oral Administration