OSW 1

01/01/2022 - "Furthermore, the mouse xenograft model confirmed the suppressive effect of OSW-1 on tumor growth in vivo. "
01/01/2022 - "OSW-1, isolated from Ornithogalum saundersiae, possesses anticancer activity against various malignant cancer cells. "
01/01/2021 - "In this regards, OSW-1, which was isolated from the bulbs of Ornithogalum saundersiae in 1992, has exhibited powerful anticancer activities in various cancers. "
01/01/2020 - "Accordingly, it also revealed significant inhibition of tumor growth by OSW-1 in xenograft model. "
06/01/2017 - "Furthermore, in a nude mouse model, OSW-1 had a powerful effect on suppressing colon tumor proliferation without significant side effects through the apoptosis pathway. "

02/01/2013 - "The extremely potent activity of OSW-1 against leukemia cells and its unique mechanism of action suggest that this compound may be potentially useful in the treatment of leukemia."
02/01/2013 - "In this study, we showed that OSW-1 effectively killed leukemia cells at subnanomolar concentrations through a unique mechanism by causing a time-dependent elevation of cytosolic Ca(2+) prior to induction of apoptosis. "
02/01/2013 - "Effective killing of leukemia cells by the natural product OSW-1 through disruption of cellular calcium homeostasis."
12/07/2005 - "Clones of leukemia cells with mitochondrial DNA defects and respiration deficiency that had adapted the ability to survive in culture without mitochondrial respiration also were resistant to OSW-1. "
12/07/2005 - "In vitro analysis revealed that OSW-1 effectively killed primary leukemia cells from chronic lymphocytic leukemia patients with disease refractory to fludarabine. "

07/01/2022 - "The therapeutic efficacy of OSW-1 on prostate cancer and its underlying mechanism are yet to be established. "
07/01/2022 - "OSW-1 inhibited the growth of prostate cancer cells by interrupting the interaction between mTOR and Rictor/mTORC2. "

06/01/2017 - "However, the therapeutic efficacy of OSW-1 on colon cancer and the underlying mechanism are not understood. "
06/01/2017 - "Taken together, these results demonstrate that OSW-1 is a potential drug for colon cancer treatment."
06/01/2017 - "Effective cytotoxic activity of OSW-1 on colon cancer by inducing apoptosis in vitro and in vivo."
06/01/2017 - "To explore the mechanism underlying OSW-1 in antitumor therapy, a therapeutic function analysis of OSW-1 on colon cancer was performed in vitro and in vivo. "
06/01/2017 - "It was shown that with low toxicity on normal colonic cells, OSW-1 suppresses colon cancer cells in vitro and this inhibition was via the intrinsic apoptotic pathway, which increased cellular calcium, changed mitochondrial membrane potential, disrupted mitochondrial morphology, and led to the release of cytochrome c and the activation of caspase-3. "

01/01/2020 - "Furthermore, we carried out transwell assays and found that OSW-1 significantly repressed the migratory and invasive capabilities of triple-negative breast cancer (TNBC) cells via mediating epithelial-mesenchymal transition. "
12/01/2022 - "OSW-1 induces apoptosis and cyto-protective autophagy, and synergizes with chemotherapy on triple negative breast cancer metastasis."
01/01/2020 - "OSW-1 inhibits tumor growth and metastasis by NFATc2 on triple-negative breast cancer."