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metallopeptidase-1

isolated from Haemonchus contortus; amino acid sequence in first source; GenBank Z75054

Also Known As:

MEP1 enzyme

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Metalloproteases: 8276
        Metalloendopeptidases: 70
        metallopeptidase-1: 4
      - Endopeptidases: 633
        Metalloendopeptidases: 70
        metallopeptidase-1: 4

Experts

1.	Cheng, Ying-Chen: 1 article (01/2020)
2.	Haung, Hsing-Yu: 1 article (01/2020)
3.	Hu, Shang-Hsiu: 1 article (01/2020)
4.	Kang, Wenyi: 1 article (01/2020)
5.	Liu, Dengyong: 1 article (01/2020)
6.	Wang, Hui-Min David: 1 article (01/2020)
7.	Wang, Yi-Chen: 1 article (01/2020)
8.	Xiao, Chaogeng: 1 article (01/2020)
9.	Bau, DA-Tian: 1 article (07/2016)
10.	Chang, Wen-Shin: 1 article (07/2016)

Related Diseases

1.	Mitochondrial Diseases (Mitochondrial Disease) 10/01/2023 - "Results: AKG administration both in vivo, and in vitro significantly suppressed the hyperlipidemia-induced endothelial damage, regulated ET-1 and nitric oxide levels, and reduced the inflammatory factor interleukin-6 and matrix metallopeptidase-1 by inhibiting oxidative stress and mitochondrial dysfunction. "
2.	B-Cell Lymphoma (Lymphoma, B Cell) 01/01/2020 - "qRT-PCR and Western blot demonstrated that TAP-nanoemulsion triggered effectively the apoptosis pathway, including enhancements of cleaved caspase-3 and caspase-9, ataxia-telangiectasia mutated kinase (ATM), and p21WAF1/CIP1 (p21) and decreases of B-cell lymphoma 2 (Bcl-2); cyclins D, D1, and E; mitogen-activated protein kinase (MEK); extracellular signal-regulated kinases (ERK); nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB); and matrix metallopeptidase-1 and metallopeptidase-9 (MMP-1 and MMP-9) in both gene and protein expressions. "
3.	Hyperlipidemias (Hyperlipidemia) 10/01/2023 - "Results: AKG administration both in vivo, and in vitro significantly suppressed the hyperlipidemia-induced endothelial damage, regulated ET-1 and nitric oxide levels, and reduced the inflammatory factor interleukin-6 and matrix metallopeptidase-1 by inhibiting oxidative stress and mitochondrial dysfunction. "
4.	Breast Neoplasms (Breast Cancer) 01/01/2013 - "Fra-1 regulation of Matrix Metallopeptidase-1 (MMP-1) in metastatic variants of MDA-MB-231 breast cancer cells."
5.	Ataxia Telangiectasia (Louis Bar Syndrome) 01/01/2020 - "qRT-PCR and Western blot demonstrated that TAP-nanoemulsion triggered effectively the apoptosis pathway, including enhancements of cleaved caspase-3 and caspase-9, ataxia-telangiectasia mutated kinase (ATM), and p21WAF1/CIP1 (p21) and decreases of B-cell lymphoma 2 (Bcl-2); cyclins D, D1, and E; mitogen-activated protein kinase (MEK); extracellular signal-regulated kinases (ERK); nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB); and matrix metallopeptidase-1 and metallopeptidase-9 (MMP-1 and MMP-9) in both gene and protein expressions. "

Related Drugs and Biologics

1.	Caspase 9
2.	Caspase 3 (Caspase-3)
3.	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)
4.	Mitogen-Activated Protein Kinase Kinases (MEKs)
5.	Mitogen-Activated Protein Kinases
6.	Cyclins
7.	Interleukin-6 (Interleukin 6)
8.	Proteins (Proteins, Gene)
9.	Phosphotransferases (Kinase)
10.	Nitric Oxide (Nitrogen Monoxide)