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sigma-1 receptor (receptor 1, sigma)

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Also Known As:

receptor 1, sigma; 28-kDa SR-BP protein, human; OPRS1 protein, human; Oprs1 protein, mouse; Oprs1 protein, rat; SIGMAR1 protein, human; SR 31747A-binding protein, human; SR-BP protein, human; mSigmaR1 protein, mouse; opioid receptor, sigma 1 protein, human; opioid receptor, sigma 1 protein, rat; opioid receptor, sigma 1, mouse; sigma-1 receptors

Networked: 152 relevant articles (16 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Membrane Proteins: 5300
    - Cell Surface Receptors: 753

Experts

1.	Hashimoto, Kenji: 21 articles (03/2015 - 03/2007)
2.	Fukunaga, Kohji: 9 articles (10/2015 - 11/2009)
3.	Roh, Dae-Hyun: 9 articles (10/2015 - 12/2008)
4.	Yoon, Seo-Yeon: 9 articles (10/2015 - 12/2008)
5.	Lee, Jang-Hern: 8 articles (10/2015 - 12/2008)
6.	Beitz, Alvin J: 8 articles (10/2015 - 12/2008)
7.	Kang, Suk-Yun: 7 articles (10/2015 - 06/2009)
8.	Zamanillo, Daniel: 7 articles (06/2015 - 06/2009)
9.	Hayashi, Teruo: 7 articles (01/2015 - 08/2003)
10.	Han, Ho-Jae: 6 articles (10/2015 - 12/2008)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 04/01/2015 - "Our results demonstrate that DTG, a sigma-1 receptor agonist, reverses some of the behavioral and neuromorphological effects of nVHL on the rat and supports the possibility that DTG may have beneficial effects in the management of symptoms of schizophrenia." 01/01/2014 - "We showed that induction of the sigma-1 receptor plays a role in the UPR, and suggested the possibility that this mechanism is impaired in disorders such as schizophrenia. " 01/01/2012 - "In this article, we review the recent findings on sigma-1 receptor agonists as potential therapeutic drugs for the treatment of cognitive impairment in schizophrenia and psychotic depression." 04/30/2009 - "Association between sigma-1 receptor gene polymorphism and prefrontal hemodynamic response induced by cognitive activation in schizophrenia." 02/01/2006 - "Sigma-1 receptors are expressed throughout the mammalian central nervous system (CNS) and are implicated in several psychiatric disorders, including schizophrenia and depression. "
2.	Hypertrophy 01/01/2013 - "We recently found very high expression of the sigma-1 receptor, an orphan receptor, in rat heart tissue and defined the cardiac sigma-1 receptor as a direct SSRI target in eliciting cardioprotection in both pressure overload (PO)induced and transverse aortic constriction (TAC)-induced myocardial hypertrophy models in rodents. " 01/15/2011 - "Interestingly, sigma-1 receptor expression in the thoracic aorta decreased significantly 4 weeks after pressure overload-induced hypertrophy in vehicle treated ovariectomized rats. " 01/15/2011 - "Thus, we demonstrate, for the first time, a potential role in the thoracic aorta for sigma-1 receptor expression and signaling via Akt-eNOS in attenuating hypertrophy-induced vascular injury in ovariectomized rats." 01/15/2011 - "Our findings confirm, for the first time, a potential role for sigma-1 receptor expression and signaling in the thoracic aorta in attenuating hypertrophy-induced vascular injury in ovariectomized rats. " 10/01/2010 - "Targeting sigma-1 receptor with fluvoxamine ameliorates pressure-overload-induced hypertrophy and dysfunctions."
3.	Delirium 09/01/2012 - "Sigma-1 receptor agonist fluvoxamine for delirium in older adults." 01/01/2010 - "Sigma-1 receptor agonist fluvoxamine for postoperative delirium in older adults: report of three cases." 01/01/2010 - "Sigma-1 receptor agonist fluvoxamine for delirium in intensive care units: report of five cases." 01/01/2010 - "Sigma-1 receptor agonist fluvoxamine for delirium in patients with Alzheimer's disease." 01/01/2010 - "We report on two cases in which monotherapy of the selective serotonin reuptake inhibitor and sigma-1 receptor agonist fluvoxamine was effective in ameliorating the delirium of patients with Alzheimer's disease. "
4.	Psychomotor Agitation (Akathisia) 01/01/2010 - "Fluvoxamine for aripiprazole-associated akathisia in patients with schizophrenia: a potential role of sigma-1 receptors." 01/01/2010 - "We report on five cases in which monotherapy of the selective serotonin reuptake inhibitor and sigma-1 receptor agonist fluvoxamine was effective in ameliorating the akathisia of patients with schizophrenia treated with the new atypical antipsychotic drug blonanserin. " 01/01/2010 - "We report on two cases in which monotherapy of the selective serotonin reuptake inhibitor and sigma-1 receptor agonist fluvoxamine was effective in ameliorating the akathisia of patients with schizophrenia treated with the antipsychotic drug aripiprazole. "
5.	Brain Injuries (Brain Injury) 03/01/2015 - "This study suggests that sigma-1 receptor agonists could be potential preventive and therapeutic drugs for perinatal brain injury, although a pharmacological experiment using a sigma-1 receptor antagonist was not performed. " 11/01/2014 - "The present study provides strong support for the consideration of sigma-1 receptor agonists as a candidate therapy for the reduction of neonatal excitotoxic brain lesions and might offer a novel target to counteract developmental brain injury. " 03/01/2015 - "Targeting the sigma-1 receptor chaperone in the treatment of perinatal brain injury." 11/01/2014 - "The observation that sigma-1 receptor agonists possess neuroprotective potential, at least partly mediated by a variety of anti-excitotoxic mechanisms, has generated great interest in targeting those receptors to counteract brain injury. " 11/01/2013 - "Neuroprotective effects of sigma-1 receptor agonists have been described previously for neonatal and adult models of brain injury. "

Related Drugs and Biologics

1.	Fluvoxamine (Luvox)
2.	Serotonin (5 Hydroxytryptamine)
3.	SA 4503
4.	Dehydroepiandrosterone (DHEA)
5.	sigma-1 receptor (receptor 1, sigma)
6.	Ligands
7.	donepezil (Aricept)
8.	Phencyclidine (Angel Dust)
9.	Adenosine Triphosphate (ATP)
10.	aripiprazole (Abilify)

Related Therapies and Procedures

1.	Analgesia
2.	Therapeutics
3.	Drug Therapy (Chemotherapy)
4.	Palliative Care (Palliative Medicine)
5.	Spinal Injections