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interleukin 16 precursor

amino acid sequence given in first source; GenBank U82972

Also Known As:

IL-16 precursor; pro-IL-16

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cruikshank, William W: 4 articles (12/2011 - 07/2003)
2.	Center, David M: 3 articles (12/2011 - 02/2004)
3.	Richmond, Jillian: 2 articles (12/2011 - 10/2011)
4.	Zhang, Yujun: 2 articles (12/2011 - 02/2004)
5.	Kornfeld, Hardy: 2 articles (09/2005 - 03/2005)
6.	Ren, Fucheng: 2 articles (09/2005 - 03/2005)
7.	Choe, C-H: 1 article (03/2013)
8.	Jang, Y-S: 1 article (03/2013)
9.	Kim, J: 1 article (03/2013)
10.	Kim, S-H: 1 article (03/2013)

Related Diseases

1.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 02/01/2004 - "In this study we have found that pro-IL-16 is absent or mutated in four T lymphoblastic leukemia cell lines examined. "
2.	Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous) 11/01/2014 - "Retraction: Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma." 12/01/2011 - "Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma."
3.	Neoplasms (Cancer) 10/01/2011 - "Therefore, we tested whether or not reintroduction of pro-IL-16 into solid tumors in mice could halt tumor growth. " 10/01/2011 - "Intracellular expression of pro-IL-16 causes these cell lines to become quiescent, implicating loss of pro-IL-16 as a contributory step in T-cell malignancy. " 03/01/2005 - "Pro-IL-16 expressed in transfected tumor cells was previously shown to translocate to the nucleus and to promote G(0)/G(1) arrest by stabilizing the cyclin-dependent kinase inhibitor p27(Kip1). "
4.	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 12/01/2011 - "T cells isolated from 11 patients with advanced CTCL, but not those from healthy controls or patients with T cell acute lymphocytic leukemia (T-ALL), demonstrated reduction in nuclear pro-IL-16 levels. "
5.	T-Cell Lymphoma (Lymphoma, T Cell) 03/01/2013 - "Given that IL-16 acts as an immunomodulator by impairing antigen-induced T cell activation and its precursor, pro-IL-16, plays a role in regulating the cell cycle in T lymphocytes and T cell lymphoma, we concluded that pro-IL-16 is involved in resting B cell proliferation, similar to its function in T lymphocytes."

Related Drugs and Biologics

1.	Cyclin-Dependent Kinase Inhibitor p27
2.	Protein Isoforms (Isoforms)
3.	Interleukin-16 (Interleukin 16)
4.	Proteins (Proteins, Gene)
5.	Immunologic Factors (Immunomodulators)
6.	Antigens