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transglutaminase 1

TRANSGLUTAMINASE 1 (TGM1 or TGK) is a membrane-associated enzyme involved in the formation of the cornified cell envelope of the EPIDERMIS; Mutations in the human gene (14q11) cause autosomal recessive lamellar ICHTHYOSIS; Distinguish from GAMMA-GLUTAMYLTRANSPEPTIDASE involved with glutathione metabolism and other protein cross-linking transglutaminase; RefSeq NM_019984 (mouse), NM_031659 (rat), NM_000359 (human)
Also Known As:
TGASE, human; TGK protein, human; TGM1 protein; TGM1 protein, human; TGase 1, mouse; Tgm1 protein, mouse; Tgm1 protein, rat; epidermal type I transglutaminase; keratinocyte transglutaminase K; transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase), human; transglutaminase 1, K polypeptide, mouse; transglutaminase 1, rat; transglutaminase K; transglutaminase TGM1; transglutaminase Type I; transglutaminase i; transglutaminase1
Networked: 99 relevant articles (1 outcomes, 3 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Rice, Robert H: 4 articles (01/2019 - 09/2005)
2. Yamanishi, Kiyofumi: 4 articles (01/2016 - 01/2002)
3. Hitomi, Kiyotaka: 4 articles (11/2015 - 04/2010)
4. Gruber, Robert: 3 articles (01/2019 - 09/2005)
5. Phinney, Brett S: 3 articles (01/2019 - 01/2013)
6. Akiyama, Masashi: 3 articles (08/2011 - 02/2007)
7. Ahvazi, Bijan: 3 articles (01/2007 - 01/2003)
8. Rice, R H: 3 articles (11/2003 - 07/2000)
9. Gao, Min: 2 articles (01/2021 - 01/2021)
10. Liu, Dan: 2 articles (01/2021 - 01/2021)

Related Diseases

1. Psoriasis (Pustulosis Palmaris et Plantaris)
2. Lamellar Ichthyosis (Harlequin Ichthyosis)
3. Inflammation (Inflammations)
01/01/2021 - "In vivo studies demonstrated that both single and repeated topical KB105 administration induced TGM1 protein expression in the target epidermal layer without triggering fibrosis, necrosis, or acute inflammation. "
12/01/2013 - "In cultured keratinocytes, the midkine gene was expressed earlier than the genes required for keratinization, for example, cytokeratin 10 and transglutaminase 1. Because midkine is expressed in the keratinized areas of normal skin, neoplasms and inflammation, it may play a role as a modulator of keratinization in the skin. "
01/01/2019 - "The effects of UV on the skin mainly include acute inflammation (erythema/edema) and abnormal keratinization wherein prostaglandin E2 (produced by cyclooxygenase-2), interleukin-8 and transglutaminase 1 (a major regulatory factor of keratinization) play pivotal roles. "
10/18/2000 - "In congenital ichthyosis, various enzyme deficiencies (transglutaminase 1, steroid sulfatase, etc) or mutations in structural proteins (cytokeratins, plakophilin, etc) cause massive hyperkeratosis and/or inflammation resulting in chronic problems with the skin barrier. "
07/01/1997 - "To further characterize the biological effects of topical calcitriol treatment in psoriasis, we have analyzed immunohistochemically the expression of markers for epidermal proliferation (proliferating cell nuclear antigen=PCNA) and differentiation (transglutaminase K, involucrin, cytokeratin 16), as well as inflammation (CD1a, 55 kDa TNF-receptor, NAP-1/IL-8) in calcitriol-treated psoriatic skin in situ. "
4. Necrosis
5. Fibrosis (Cirrhosis)

Related Drugs and Biologics

1. paricalcitol (Zemplar)
2. Enzymes
3. Keratins (Keratin)
4. Proteins (Proteins, Gene)
5. loricrin
6. Messenger RNA (mRNA)
7. involucrin
8. ErbB Receptors (EGF Receptor)
9. Proliferating Cell Nuclear Antigen (PCNA)
10. Transglutaminases

Related Therapies and Procedures

1. Therapeutics