8-bromoadenosine-3',5'-cyclic monophosphorothioate

Also Known As:

Rp-8-Br-cAMPS; Sp-8-Br-cAMPS

Networked: 6 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thionucleotides
    - 8-bromoadenosine-3',5'-cyclic monophosphorothioate: 6
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleotides: 140
        Adenine Nucleotides: 1066
        Cyclic AMP: 3171
        8-Bromo Cyclic Adenosine Monophosphate: 94
        8-bromoadenosine-3',5'-cyclic monophosphorothioate: 6

Experts

1.	Aandahl, Einar M: 2 articles (12/2011 - 06/2008)
2.	Taskén, Kjetil: 2 articles (12/2011 - 06/2008)
3.	Abbas, Nasir: 1 article (01/2016)
4.	Hussain, Muzammal: 1 article (01/2016)
5.	Javeed, Aqeel: 1 article (01/2016)
6.	Mukhtar, Muhammad Mahmood: 1 article (01/2016)
7.	Shah, Zahir: 1 article (01/2016)
8.	Zhang, Jiancun: 1 article (01/2016)
9.	Hara, Shuichi: 1 article (03/2012)
10.	Kobayashi, Masamune: 1 article (03/2012)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2016 - "Collateral data indicate that Rp-8-Br-cAMPS has shown immune-rescuing potential in terms of enhancing the innate and adaptive anti-tumor immunity, as well as protecting adaptive T cells from the suppressive effects of Tregs. " 06/01/2008 - "Furthermore, the COX inhibitor indomethacin and the PKA type I antagonist Rp-8-Br-cAMPS significantly improved the anti-tumor immune activity. "
2.	Inflammation (Inflammations) 09/01/2004 - "Neutrophils not stimulated by cAMP-elevating agents showed increased apoptosis when exposed to the cA-PK inhibitors Rp-8-Br-cAMPS and H-89, suggesting that even moderate activation of cA-PK is sufficient to enhance neutrophil longevity and thereby contribute to neutrophil accumulation in chronic inflammation."
3.	Infections 06/01/2009 - "Rp-8-Br-cAMPs reduced CLDN1 expression at the basal membrane and inhibited HCV infection, supporting a model where the nonjunctional pools of CLDN1 have a role in HCV entry. "
4.	Colonic Neoplasms (Colon Cancer) 12/15/2011 - "Parallel experiments in a human colon cancer cell line (HCT116) revealed that Rp-8-Br-cAMPS blocked PGE(2)-induced β-catenin phosphorylation and c-Myc upregulation. "
5.	Carbon Monoxide Poisoning (Poisoning, Carbon Monoxide) 03/15/2012 - "These roles might contribute to the production of hydroxyl radicals concomitant with cAMP in carbon monoxide poisoning, because the formation of 2,3-DHBA was potentiated by the PKA inhibitor H89 and suppressed by Rp-8-Br-cAMPS, which inhibits PKA and Epac."

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