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coxsackie-adenovirus receptor

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Also Known As:

CAR (coxsackie-adenovirus receptor); CAR coxsackie virus and adenovirus receptor protein, human; CLMP protein, human; CXADR protein, human; CXADR protein, mouse; coxsackie virus and adenovirus receptor protein, human; coxsackie- and adenovirus receptor-like membrane protein, human; coxsackievirus and adenovirus receptor, mouse

Networked: 113 relevant articles (1 outcomes, 7 trials/studies)

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Membrane Proteins: 5300
    - Cell Surface Receptors: 753
      - Virus Receptors: 59
        coxsackie-adenovirus receptor: 113

Experts

1.	Curiel, David T: 14 articles (06/2008 - 03/2002)
2.	Hemminki, Akseli: 12 articles (04/2012 - 03/2002)
3.	Kanerva, Anna: 10 articles (04/2012 - 03/2002)
4.	Wang, Minghui: 7 articles (06/2008 - 09/2003)
5.	Alvarez, Ronald D: 7 articles (06/2008 - 03/2002)
6.	Curiel, D T: 7 articles (05/2008 - 03/2001)
7.	Kangasniemi, Lotta: 4 articles (04/2012 - 05/2006)
8.	Zhu, Zeng B: 4 articles (06/2008 - 07/2004)
9.	Siegal, Gene P: 4 articles (06/2008 - 07/2004)
10.	Rauen, Katherine A: 4 articles (09/2005 - 07/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2012 - "In vitro and in vivo studies demonstrate that Coxsackie adenovirus receptor (CAR) or foliate receptor (FR)-mediated uptake of FA-Ad-loaded PTX induced highly anti-tumor activity. " 01/01/2014 - "As many tumor tissue and cancer cells express low level of coxsackie-adenovirus receptor (CAR), which is the functional receptor for the fiber protein of human adenovirus serotype 5 (Ad5), novel Ad5 vectors containing genetically modifi ed fiber are attractive vehicles for achieving targeted gene transfer and improving suicide gene expression in these cancer cells. " 01/01/2013 - "The use of adenoviral vector for gene therapy is still an important strategy for advanced cancers, however, the lack of the requisite coxsackie-adenovirus receptor in cancer cells and host immune response to adenovirus limit the application of adenoviral vector in vivo. " 04/15/2012 - "As expression of the coxsackie-adenovirus receptor may be variable in advanced tumors, we developed Ad5-D24-RGD, a p16/Rb pathway selective oncolytic adenovirus featuring RGD-4C modification of the fiber. " 12/01/2011 - "The clinical application for systemic administration of adenoviral (Ad) vectors is limited, as these vectors do not efficiently penetrate solid tumor masses due to a common deficiency of Coxsackie Adenovirus Receptor (CAR) on the tumor surface. "
2.	Infection 05/01/2006 - "Most studies utilized adenovirus serotype 5 (Ad5) based vectors, which as adhesion molecules require the coxsackie adenovirus receptor (CAR) as a critical determinant for cellular infection. " 12/01/2015 - "We also prepared replication-competent Ad5 that were activated with the same region but had the type 35 Ad-derived fiber-knob region (AdF35) to convert the major cellular receptor for Ad infection from the coxsackie adenovirus receptor to CD46 molecules. " 06/01/2015 - "Although replication-defective adenoviruses provide an attractive alternative for gene delivery, their use has been hampered by the limited susceptibility of murine leukocytes to adenoviral infection, due to insufficient expression of the human coxsackie/adenovirus receptor (CAR). " 03/01/2007 - "HDACi treatment increased coxsackie-adenovirus receptor (CAR) expression, resulting in increased adenoviral infection, and increased TRAIL-mediated killing. " 01/01/2007 - "Many target cells, however, express low levels of Ad5 native receptor, the Coxsackie-Adenovirus Receptor (CAR), and thus are resistant to Ad5 infection. "
3.	Adenoviridae Infections (Adenovirus Infections) 01/01/2001 - "Manipulation of the cytoplasmic and transmembrane domains alters cell surface levels of the coxsackie-adenovirus receptor and changes the efficiency of adenovirus infection." 10/01/2000 - "Many cell types, including lymphocytes, are refractory to adenovirus infection because they lack the Coxsackie/adenovirus receptor (CAR) needed for virus attachment. " 10/01/2000 - "Expression of a human coxsackie/adenovirus receptor transgene permits adenovirus infection of primary lymphocytes." 01/01/2005 - "Unfortunately, recent data suggest that the primary receptor, the coxsackie-adenovirus receptor (CAR) expression in tumors may be highly variable resulting in resistance to adenovirus infection. " 06/01/2005 - "This study engineered an Epstein-Barr virus-transformed B-lymphoblastoid cell line permissive to adenovirus infection and elucidated key roles for both the coxsackie-adenovirus receptor and alphavbeta5 integrin in mediating entry of adenoviruses into these cells. "
4.	Urinary Bladder Neoplasms (Bladder Cancer) 07/01/2004 - "Studies on bladder cancer cell lines have shown that low adenoviral (Ad) infectivity is associated with low-level coxsackie adenovirus receptor (CAR) expression. " 07/01/2004 - "Histone deacetylase inhibitors upregulate expression of the coxsackie adenovirus receptor (CAR) preferentially in bladder cancer cells." 09/01/2002 - "Integrin alpha(v) and coxsackie adenovirus receptor expression in clinical bladder cancer." 10/15/2006 - "Etoposide also increased adenoviral infection via enhancement of coxsackie-adenovirus receptor expression on bladder cancer and normal cells. " 07/01/2006 - "Reverse transcriptase polymerase chain reaction analysis was used to determine expression patterns of BSP and Coxsackie adenovirus receptor, a receptor known to interact with adenovirus, on multiple lines of bladder cancer (253J, 253J B-V, RT4, transitional cell carcinoma, T24, UMUC3, and WH). "
5.	Cardiomyopathies (Cardiomyopathy) 10/10/2011 - "The receptor of the two most common viruses connected to these myocardial diseases was identified as Coxsackie-Adenovirus Receptor. " 05/01/2011 - "The coxsackie-adenovirus receptor induces an inflammatory cardiomyopathy independent of viral infection." 01/01/2003 - "The induction of the coxsackie-adenovirus receptor (CAR) exclusively in 63% of DCM patients, but not in other cardiomyopathies, might constitute a key molecular determinant for cardiotropic viral infections in DCM. " 10/10/2011 - "The purpose of this study was to assess Coxsackie-Adenovirus Receptor mRNA expression in the myocardium and search for mutations in the Coxsackie-Adenovirus Receptor gene to compare dilated, inflammatory and ischemic cardiomyopathy with control group. " 10/10/2011 - "No mutation but high mRNA expression of Coxsackie-Adenovirus Receptor was observed in both dilated and ischemic cardiomyopathy."

Related Drugs and Biologics

1.	AD 5
2.	Integrin alphaV
3.	Protein Isoforms (Isoforms)
4.	Messenger RNA (mRNA)
5.	Hormones
6.	integrin alphaVbeta5
7.	Integrins
8.	adenovirus receptor
9.	Histone Deacetylase Inhibitors
10.	RNA-Directed DNA Polymerase (Reverse Transcriptase)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Castration