Z1046

a mixed D1/D2-like agonist that reduces peripheral and renal vascular resistance increasing renal blood flow

Also Known As:

(S)-6-((6-((2-(2-methoxyphenoxy)ethyl)amino)hexyl)propylamino)-5,6,7,8-tetrahydro-1,2-naphtalenediol, dihydrochloride; Z-1046

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

1.	Left Ventricular Dysfunction 03/01/1997 - "1. In view of the potential therapeutic application of specific dopamine receptor agonists in the treatment of hypertension and left ventricular dysfunction, we investigated the cardiovascular actions of the novel mixed D1/D2 dopamine receptor agonist Z1046 in awake pigs at rest and during treadmill exercise. "
2.	Myocardial Ischemia (Ischemic Heart Diseases) 01/01/1997 - "The inhibition of NE could be the basis of Z1046 potent cardioprotective effect observed in a dog model of myocardial ischemia and reperfusion, in which the severity of ventricular arrhythmias was markedly reduced, resulting in higher survival. "
3.	Infarction (Infarctions) 09/01/1997 - "Infarct size was significantly reduced both by Z1046 and by ibopamine (P < .05). "
4.	Hypotension (Low Blood Pressure) 09/01/1997 - "In conclusion, Z1046 produced systemic hypotension with negligible reflex activation of sympathetic tone."
5.	Hypertension (High Blood Pressure) 03/01/1997 - "1. In view of the potential therapeutic application of specific dopamine receptor agonists in the treatment of hypertension and left ventricular dysfunction, we investigated the cardiovascular actions of the novel mixed D1/D2 dopamine receptor agonist Z1046 in awake pigs at rest and during treadmill exercise. "

1.	ibopamine
2.	Dopamine Agonists (Dopamine Agonist)