heme oxygenase-2

together with HO-1, catalyzes the cleavage of heme to produce biliverdin IXalpha, CO & Fe; constitutively expressed in many mammalian tissues; not induced by inducers of heme oxygenase-1; has been sequenced

Also Known As:

Networked: 60 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Furuyama, Kazumichi: 5 articles (01/2010 - 07/2004)
2.	Shibahara, Shigeki: 5 articles (01/2010 - 07/2004)
3.	Takeda, Kazuhisa: 5 articles (01/2010 - 07/2004)
4.	Regan, Raymond F: 4 articles (08/2014 - 11/2005)
5.	Ishikawa, Kazunobu: 4 articles (01/2010 - 07/2004)
6.	Doré, Sylvain: 3 articles (02/2016 - 07/2003)
7.	Date, Fumiko: 3 articles (01/2010 - 07/2004)
8.	Ogawa, Kazuhiro: 3 articles (07/2006 - 07/2004)
9.	Zhang, Yongzhao: 3 articles (07/2006 - 07/2004)
10.	Gridina, Anna: 2 articles (01/2021 - 01/2017)

Related Diseases

1.	Diaschisis 07/01/2018 - "In conclusion, these findings suggest that heme oxygenase-2 is involved in mechanisms by which not only protects against compromised energy metabolism of the ipsilateral hemisphere but also ameliorates transhemispheric diaschisis of the contralateral hemisphere in ischemic brain." 07/01/2018 - "Quantitative imaging mass spectroscopy reveals roles of heme oxygenase-2 for protecting against transhemispheric diaschisis in the brain ischemia."
2.	Hypoxia (Hypoxemia) 01/01/2022 - "In conclusion, this study adds information on genetic factors involved in individual vulnerability to acute hypoxia and supports the critical role of the ≪ O2 sensor ≫ - heme oxygenase-2 - in the chemosensitivity of carotid bodies in Humans." 03/26/2010 - "Enhanced translation of heme oxygenase-2 preserves human endothelial cell viability during hypoxia." 01/01/2009 - "We have shown previously that the cardiorespiratory regions of the rostral ventrolateral medulla are excited by local hypoxia and that heme oxygenase-2 (HO-2) is expressed in the hypoxia-chemosensitive regions of the rostral ventrolateral medulla (RVLM), the respiratory pre-Bötzinger complex, and C1 sympathoexcitatory region. " 07/01/2006 - "Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines. " 07/23/2004 - "Hypoxemia and blunted hypoxic ventilatory responses in mice lacking heme oxygenase-2."
3.	Stroke (Strokes) 07/01/2018 - "This study aims to examine whether heme oxygenase-2 plays a protective role in mice against stroke. " 01/01/2005 - "Stroke outcomes in mice lacking the genes for neuronal heme oxygenase-2 and nitric oxide synthase."
4.	Pre-Eclampsia (Preeclampsia) 02/01/2013 - "This study aims to analyze the regulation relationship between HSP90α and heme oxygenase-2 (HO-2) in cord blood RBC during preeclampsia. "
5.	Hirschsprung Disease (Hirschsprung's Disease) 01/01/2002 - "An experimental study on the expression of heme oxygenase-2 mRNA in Hirschsprung's disease." 01/01/2002 - "In order to investigate the relationship between the expression of heme oxygenase-2 (HO-2) mRNA and the pathogenesis of Hirschsprung's disease (HD), total ribonucleic acid (RNA) was extracted in the aganglionic and ganglionic segments of colon respectively from 15 cases of HD. "

Related Drugs and Biologics

1.	Heme Oxygenase-1
2.	Messenger RNA (mRNA)
3.	Proteins (Proteins, Gene)
4.	Heme (Haem)
5.	Protein Isoforms (Isoforms)
6.	Oxygen (Dioxygen)
7.	Enzymes
8.	Carbon Monoxide
9.	Endothelin-1 (Endothelin 1)
10.	Nitric Oxide Synthase (NO Synthase)