TAK 187

structure in first source; ergosterol biosynthesis inhibitor with possible usage against Trypanosoma

Also Known As:

2-(2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-4-(4-(2,2,3,3-tetrafluoropropoxy)phenyl)-3(2H,4H)-1,2,4-triazolone; TAK-187

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Halogenated Hydrocarbons: 42
    - Fluorinated Hydrocarbons: 4
      - Fluorocarbons: 1209
        TAK 187: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - TAK 187: 3

Experts

1.	Urbina, Julio A: 2 articles (04/2005 - 01/2003)
2.	Basombrío, Miguel Angel: 1 article (04/2005)
3.	Cardozo, Rubén: 1 article (04/2005)
4.	Corrales, Milagros: 1 article (04/2005)
5.	Segura, María Asunción: 1 article (04/2005)
6.	Brener, Zigman: 1 article (01/2003)
7.	Lira, Renee: 1 article (01/2003)
8.	Molina, Judith: 1 article (01/2003)
9.	Payares, Gilberto: 1 article (01/2003)
10.	Romanha, Alvaro J: 1 article (01/2003)

Related Diseases

1.	Infections 10/01/1998 - "Based upon its therapeutic efficacy and long half-life in the rabbit model, TAK-187 should be investigated for intermittent dosing in treatment or suppression of cryptococcal infections in humans."
2.	Chagas Disease (American Trypanosomiasis) 01/01/2003 - "Parasitological cure of acute and chronic experimental Chagas disease using the long-acting experimental triazole TAK-187. " 04/01/2005 - "We carried out a comparative study of benznidazole and TAK-187, a long-lasting ergosterol biosynthesis inhibitor, with a murine model of Chagas' disease. " 04/01/2005 - "Comparative efficacies of TAK-187, a long-lasting ergosterol biosynthesis inhibitor, and benznidazole in preventing cardiac damage in a murine model of Chagas' disease."
3.	Cryptococcal Meningitis 10/01/1998 - "TAK-187 also was evaluated as intermittent therapy using two dosages in a rabbit model of experimental cryptococcal meningitis. "

Related Drugs and Biologics

1.	Triazoles
2.	Ergosterol (Lumisterol)
3.	benzonidazole (benznidazole)

Related Therapies and Procedures

1.	Therapeutics