L 741671
structure given in first source
Also Known As:
5-(((3-(3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidino)methyl)-3-oxo-1,2,4-triazole; L-741,671
Networked: 1
relevant articles (0 outcomes,
0 trials/studies)
Bio-Agent Context: Research Results
Related Diseases
| 1. | Vomiting
01/01/1996
- " L-741,671 and L-743,310 had equivalent functional activity, at the same dose, against cisplatin-induced emesis when injected centrally. " 01/01/1996
- " When tested against cisplatin-induced emesis in ferrets, L-741,671 (0.3, 1 and 3 mg/kg i.v.) produced marked dose-dependent inhibition of retching and vomiting but L-743,310 was inactive at 3 and 10 micrograms/kg i.v. In contrast, direct central injection of L-741,671 and L-743,310 (30 micrograms) into the vicinity of the nucleus tractus solitarius or L-743,310 (200 micrograms) intracisternally was shown to inhibit retching and vomiting induced by i.v. cisplatin. "
|
|
Related Drugs and Biologics