interleukin 1beta-converting enzyme 2

FLICE2 - FADD-Like ICE 2; similar to interleukin-1beta converting enzyme (FLICE/MACH/ICE/Ced-3); involved in CD95- & p55-mediated death signaling; amino acid sequence given in first source

Also Known As:

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chung, Ho-Sam: 1 article (12/2003)
2.	Huh, Sung-Jin: 1 article (12/2003)
3.	Paik, Doo-Jin: 1 article (12/2003)
4.	Youn, Jeehee: 1 article (12/2003)
5.	Jang, Ja June: 1 article (06/2002)
6.	Kang, Chang Suk: 1 article (06/2002)
7.	Kim, Chul Woo: 1 article (06/2002)
8.	Kim, Hong Sug: 1 article (06/2002)
9.	Kim, Sang Ho: 1 article (06/2002)
10.	Kim, Su Young: 1 article (06/2002)

Related Diseases

1.	Autoimmune Lymphoproliferative Syndrome 06/01/2002 - "Caspase 10 (Mch4/FLICE2) is a caspase homologous to caspase 8. A recent report described that inherited CASP10 gene mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome (ALPS). "
2.	Hyperplasia 12/15/2003 - "Thus, these results suggest that over-expression of GRB2 and FLICE2 in RA synovium is caused by TNF-alpha inducibility differentially regulated in RA synoviocytes and provide potential pathogenic roles of these genes in the hyperplasia of the RA synovium."

Related Drugs and Biologics

1.	Caspase 10
2.	Caspase 8 (Caspase-8)
3.	Caspases
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)