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2-(allylthio)pyrazine

structure given in first source

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrazines: 150
    - 2-(allylthio)pyrazine: 9

Experts

1.	Kim, N D: 3 articles (07/2001 - 02/2001)
2.	Cho, Min Kyung: 1 article (04/2003)
3.	Kim, Dong-Hyun: 1 article (04/2003)
4.	Kim, Sang Geon: 1 article (04/2003)
5.	Kwon, Jong Won: 1 article (04/2003)
6.	Lee, Myung Gull: 1 article (04/2003)
7.	Yim, Yoon Gyoon: 1 article (04/2003)
8.	Ha, J R: 1 article (07/2001)
9.	Kang, K W: 1 article (07/2001)
10.	Kim, C W: 1 article (07/2001)

Related Diseases

1.	Carcinogenesis 05/26/2001 - "An investigation was conducted to assess the chemopreventive effects of 2-(allylthio)pyrazine (2-AP), synthesized for potential use as a chemopreventive agent, after administration during the pre-initiation and post-initiation stages in a rat colon carcinogenesis model with azoxymethane (AOM). " 05/26/2001 - "Chemopreventive effect of 2-(allylthio)pyrazine (2-AP) on rat colon carcinogenesis induced by azoxymethane (AOM)." 09/01/1999 - "2-(Allylthio)pyrazine (2-AP), a pyrazine derivative of allylsulfide synthesized for use as a chemoprotective agent, has been shown to protect against experimental carcinogenesis and mutagenesis. " 07/01/1998 - "Chemopreventive effects of 2-(allylthio)pyrazine on hepatic lesion, mutagenesis and tumorigenesis induced by vinyl carbamate or vinyl carbamate epoxide."
2.	Neoplasms (Cancer) 07/01/2001 - "2-(Allylthio)pyrazine, a cancer chemopreventive agent, inhibits liver fibrosis induced by dimethylnitrosamine in rats: role of inhibition of transforming growth factor-beta1 expression." 02/01/2001 - "2-(Allylthio)pyrazine derivatives were designed as a novel cancer chemopreventive agent that functions through selective inhibtion of cytochrome P-450 and induction of phase II enzymes involved in the detoxification of carcinogens. " 01/01/1999 - "In brief, ascorbic acid, soybean lecithin, capsaicin, biochanin A, Ganoderma lucidum, caffeine, and a novel synthetic 2-(allylthio)pyrazine decrease the incidence of mouse lung tumors, whereas fresh ginseng (4 years old), carrot, spinach, Sesamum indicum, beta-carotene, and 13-cis retinoic acid do not. "
3.	Endotoxemia 10/09/1997 - "Inhibition of inducible nitric oxide synthase expression and stimulation of the endothelial formation of nitric oxide most likely accounts for the protective effect of 2-(allylthio)pyrazine in a murine model of endotoxemia."
4.	Protein-Energy Malnutrition (Marasmus) 04/14/2003 - "Effects of cysteine on the pharmacokinetics of intravenous 2-(allylthio)pyrazine, a new chemoprotective agent, in rats with protein-calorie malnutrition." 04/14/2003 - "The effects of cysteine on the pharmacokinetics of 2-(allylthio)pyrazine (2-AP) were investigated after intravenous administration of the drug (50 mg/kg) to control (Sprague-Dawley) rats (4-week fed on 23% casein diet), and rats with protein-calorie malnutrition (PCM, 4-week fed on 5% casein diet) and PCMC (PCM with 250 mg/kg of oral cysteine, twice daily starting from the fourth week). "
5.	Liver Cirrhosis (Hepatic Cirrhosis) 07/01/2001 - "Masson's trichrome staining showed that dimethylnitrosamine induced liver fibrosis, the extent of which was reduced by 2-(allylthio)pyrazine treatments. " 07/01/2001 - "2-(Allylthio)pyrazine, a cancer chemopreventive agent, inhibits liver fibrosis induced by dimethylnitrosamine in rats: role of inhibition of transforming growth factor-beta1 expression." 07/01/2001 - "These results demonstrated that 2-(allylthio)pyrazine might inhibit dimethylnitrosamine-induced liver fibrosis due to suppression of CYP2E1 expression and transforming growth factor-beta1 production."

Related Drugs and Biologics

1.	Lecithins
2.	Transforming Growth Factor beta1 (TGF beta 1)
3.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
4.	Cytochrome P-450 CYP2E1 (CYP2E1)
5.	beta Carotene (Betacarotene)
6.	Tretinoin (Retinoic Acid)
7.	Pyrazines
8.	Nitric Oxide (Nitrogen Monoxide)
9.	Enzymes
10.	Dimethylnitrosamine (Nitrosodimethylamine)

Related Therapies and Procedures

1.	Intravenous Administration
2.	Oral Administration