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1-nitro-9-(2'-hydroxyethylamino)acridine hydrochloride

Also Known As:

C 857; C-857

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Acridines: 325
      - Aminoacridines: 3
        1-nitro-9-(2'-hydroxyethylamino)acridine hydrochloride: 5

Experts

1.	Konopa, Jerzy: 2 articles (07/2012 - 10/2007)
2.	Ashok, Badithe T: 2 articles (10/2007 - 09/2005)
3.	Aralica, Gorana: 1 article (10/2014)
4.	Catela Ivković, Tina: 1 article (10/2014)
5.	Kapitanović, Sanja: 1 article (10/2014)
6.	Lončar, Božo: 1 article (10/2014)
7.	Čačev, Tamara: 1 article (10/2014)
8.	Augustin, Ewa: 1 article (07/2012)
9.	Henderson, Colin: 1 article (07/2012)
10.	Jagiełło, Karolina: 1 article (07/2012)

Related Diseases

1.	Neoplasms (Cancer) 09/16/2005 - "The present study was undertaken to correlate the mutagenicity of C-857, C-1748, C-1790, C-1872 and C-1873 with their cytotoxicity and their anti-tumor efficacy. " 10/01/2007 - "C-1748, a DNA intercalating agent has been derived from its precursor C-857 that was a potent anti-cancer drug, but failed clinical development due to "high" systemic toxicities. "
2.	Colonic Neoplasms (Colon Cancer) 10/01/2014 - "The aim of our study was to examine the allelic frequencies of TNFα promoter SNPs, -1031 T/C, -857 C/T, -308 G/A and -238 G/A, in patients with sporadic colon adenocarcinoma in order to investigate the possible role of these SNPs in susceptibility to sporadic colon cancer. "
3.	Ehrlich Tumor Carcinoma 04/15/1989 - "The treatment of HeLa S3 cells in culture or Ehrlich ascites tumor cells in vivo with nitracrine and two other antitumor 1-nitro-9-aminoacridines, denoted C-857 and C-1006, resulted in covalent binding of these compounds to cellular DNA. "
4.	Hypoxia (Hypoxemia) 07/01/2012 - "We investigated the metabolites of C-1748 and C-857 formed in rat and human liver microsomes, with human P450 reductase (POR) and in HepG2 cells under normoxia and hypoxia. "

Related Drugs and Biologics

1.	9- (2'- hydroxyethylamino)- 4- methyl- 1- nitroacridine
2.	A-Form DNA (A-DNA)
3.	Oxidoreductases (Dehydrogenase)
4.	Nitracrine (C 283)
5.	Intercalating Agents
6.	DNA (Deoxyribonucleic Acid)