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prelamin A endoprotease

catalyzes conversion of 74-kDa lamin A precursor to 72-kDa lamin A; dependent on farnesylation

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Endopeptidases: 633
        prelamin A endoprotease: 2

Experts

1.	Auclair, M: 2 articles (03/2009 - 01/2009)
2.	Camozzi, D: 2 articles (03/2009 - 01/2009)
3.	Capanni, C: 2 articles (03/2009 - 01/2009)
4.	Caron, M: 2 articles (03/2009 - 01/2009)
5.	D'Apice, M R: 2 articles (03/2009 - 01/2009)
6.	Dominici, S: 2 articles (03/2009 - 01/2009)
7.	Fiori, V: 2 articles (03/2009 - 01/2009)
8.	Lattanzi, G: 2 articles (03/2009 - 01/2009)
9.	Le Dour, C: 2 articles (03/2009 - 01/2009)
10.	Magnani, M: 2 articles (03/2009 - 01/2009)

Related Diseases

1.

Progeria (Hutchinson Gilford Syndrome)

03/31/2009 - "Using these antibodies, we demonstrated that inhibition of the prelamin A endoprotease ZMPSTE24 mostly elicits accumulation of full-length prelamin A in its farnesylated form, while loss of the prelamin A cleavage site causes accumulation of carboxymethylated prelamin A in progeria cells. "
01/01/2009 - "Using these antibodies, we demonstrated that inhibition of the prelamin A endoprotease ZMPSTE24 mostly elicits accumulation of full-length prelamin A in its farnesylated form, while loss of the prelamin A cleavage site causes accumulation of carboxymethylated prelamin A in progeria cells. "

Related Drugs and Biologics

1.	Antibodies
2.	prelamin A