methyl arachidonylfluorophosphonate

inhibits both cytoplasmic type IV and cytosolic calcium-independent and calcium-dependent phospholipase A2

Also Known As:

MAFP cpd; Me-arachidonyl-FPO2; methyl arachidonyl fluorophosphonate; methylarachidonoylfluorophosphonate; phosphonofluoridic acid methyl-5,8,11,14-eicosatetraenyl ester

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Osada-Oka, Mayuko: 2 articles (09/2008 - 11/2006)
2.	Farooqui, Akhlaq A: 1 article (06/2015)
3.	Farooqui, Tahira: 1 article (06/2015)
4.	Kokotos, George: 1 article (06/2015)
5.	Ong, Wei-Yi: 1 article (06/2015)
6.	Antalis, Caryl: 1 article (08/2012)
7.	Cai, Qingchun: 1 article (08/2012)
8.	Del Priore, Giuseppe: 1 article (08/2012)
9.	Hamed, Ali Hassan: 1 article (08/2012)
10.	Schilder, Jeanne M: 1 article (08/2012)

Related Diseases

1.	Carcinogenesis 08/01/2012 - "S4 ascites stimulated tumorigenesis/metastasis in vivo, and methyl arachidonyl fluorophosphonate was highly effective in inhibiting EOC metastasis in mouse xenograft models. "
2.	Neoplasm Metastasis (Metastasis) 08/01/2012 - "S4 ascites stimulated tumorigenesis/metastasis in vivo, and methyl arachidonyl fluorophosphonate was highly effective in inhibiting EOC metastasis in mouse xenograft models. "
3.	Ascites 08/01/2012 - "S4 ascites stimulated tumorigenesis/metastasis in vivo, and methyl arachidonyl fluorophosphonate was highly effective in inhibiting EOC metastasis in mouse xenograft models. "
4.	Hypoxia (Hypoxemia) 09/01/2008 - "An inhibitor of phospholipase A(2), methyl arachidonyl fluorophosphonate (MAFP), and inhibitors of P450s inhibited the VEGF and EPO induction of HUAEC and Hep3B, respectively, under hypoxia. " 11/07/2006 - "An inhibitor of both iPLA2 and cPLA2, methyl arachidonyl fluorophosphonate (MAFP), prevented hypoxia-induced erythropoietin mRNA expression without affecting HIF-1alpha accumulation in Hep3B cells. "
5.	Nervous System Diseases (Neurological Disorders) 06/17/2015 - "Several old and new synthetic inhibitors of PLA2, including fatty acid trifluoromethyl ketones; methyl arachidonyl fluorophosphonate; bromoenol lactone; indole-based inhibitors; pyrrolidine-based inhibitors; amide inhibitors, 2-oxoamides; 1,3-disubstituted propan-2-ones and polyfluoroalkyl ketones as well as phytochemical based PLA2 inhibitors including curcumin, Ginkgo biloba and Centella asiatica extracts have been discovered and used for the treatment of neurological disorders in cell culture and animal model systems. "

Related Drugs and Biologics

1.	Phytochemicals
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3.	Messenger RNA (mRNA)
4.	Phospholipases (Phospholipase)
5.	Ketones
6.	Fatty Acids (Saturated Fatty Acids)
7.	Erythropoietin
8.	Curcumin
9.	Amides
10.	6- (bromomethylene)tetrahydro- 3- (1- naphthaleneyl)- 2H- pyran- 2- one