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2-butanone oxime (MEKO)

RN in first source; used extensively in paints, resins & adhesives

Also Known As:

MEKO; methylethyl ketoxime

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Hydroxylamines: 16
    - Oximes: 1292
      - 2-butanone oxime: 5
- Ketones: 2618
  - Butanones
    - 2-butanone oxime: 5

Experts

1.	Tsitsiashvili, E: 1 article (09/2007)
2.	Derelanko, Michael J: 1 article (08/2003)
3.	Rinehart, William E: 1 article (08/2003)
4.	Rodwell, Dean E: 1 article (08/2003)
5.	Bolte, H F: 1 article (12/2001)
6.	Derelanko, M J: 1 article (12/2001)
7.	Hardisty, J F: 1 article (12/2001)
8.	Newton, P E: 1 article (12/2001)
9.	Rinehart, W E: 1 article (12/2001)
10.	Wooding, W L: 1 article (12/2001)

Related Diseases

1.	Body Weight (Weight, Body) 08/01/2003 - "Body weight gains were reduced at 24 and 40 mg/kg. The preliminary study indicated maternal hematological effects in the rabbits similar to the rats at dose levels as low as 10 mg/kg. MEKO was not considered to have produced any treatment-related gestational effects, malformations or developmental variations in the rabbit at dose levels at or below 24 mg/kg. Because of excessive maternal mortality and abortions at the 40 mg/kg dose level, only 6 rabbits produced litters. "
2.	Neoplasms (Cancer) 12/29/2022 - "The induction of tumors, the nature and importance of tumors for humans, and the sensitivity of the 2 species tested, both sexes - all of these factors support the classification of MEKO into the carcinogenicity category 1B. " 02/01/1999 - "Acetoxime and methylethyl ketoxime (MEKO) are tumorigenic in rodents, inducing liver tumors in male animals. "
3.	Liver Neoplasms (Liver Cancer) 12/29/2022 - "The risk of additional liver cancer in the case of 40-year occupational exposure to MEKO is 4:100 000 at a concentration of approx. "
4.	Leukemia 12/01/2001 - "An increase in hepatocellular carcinomas occurred in male mice at 374 ppm. Additional MEKO-related findings in the rat included congestion of the spleen with pigment in reticuloendothelial cells and extramedullary hematopoiesis and a decreased incidence of lymphoreticular mononuclear cell leukemia. "
5.	Hepatocellular Carcinoma (Hepatoma) 12/01/2001 - "An increase in hepatocellular carcinomas occurred in male mice at 374 ppm. Additional MEKO-related findings in the rat included congestion of the spleen with pigment in reticuloendothelial cells and extramedullary hematopoiesis and a decreased incidence of lymphoreticular mononuclear cell leukemia. "

Related Drugs and Biologics

1.	2-butanone oxime (MEKO)
2.	acetoxime