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GSC 150

structure in first source

Also Known As:

3'-sulfo-Gal-1-4-(Fuc-1-3)GlcNAc; GSC-150

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycolipids: 2799
    - Glycosphingolipids: 1659
      - GSC 150: 1
Lipids: 114793
- Glycolipids: 2799
  - Glycosphingolipids: 1659
    - GSC 150: 1
- Membrane Lipids: 1591
  - Sphingolipids: 3208
    - Glycosphingolipids: 1659
      - GSC 150: 1

Experts

1.	Irimura, T: 1 article (03/2001)
2.	Kato, Y: 1 article (03/2001)
3.	Kondo, H: 1 article (03/2001)
4.	Shirota, K: 1 article (03/2001)
5.	Sugiyama, Y: 1 article (03/2001)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2001 - "These findings imply that the anti-metastatic effect of GSC-150 in vivo could be explained by its inhibition of cell-cell interactions between cancer and host cells." 03/01/2001 - "The number of cancer nodules found in BALB/c nude mouse liver 6 weeks after intrasplenic injection of KM12-HX cells was significantly reduced by co-administration of GSC-150. " 03/01/2001 - "The amount of [3H]thymidine-labeled KM12-HX cells distributed in liver was also significantly reduced by GSC-150 co-administration in lipopolysaccharide (LPS)-treated mice at 48 h after administration of the tumor cells, while GSC-150 did not reduce the amount of HX cells distributed at 30 min. Considering our previous report that the initial phase of the distribution of KM12-HX cells in liver is governed by their being trapped in the hepatic microvessels because of their large size (Mizuno et al., J. "
2.	Neoplasm Metastasis (Metastasis) 03/01/2001 - "Hepatol., 28, 865-877, 1998), these results suggest that GSC-150 does not inhibit this first-pass trapping by microvessels, but inhibits the subsequent process which is more directly related to final metastasis. " 03/01/2001 - "We investigated the inhibitory effect of the sialyl Lewis-X (sLeX) analog, GSC-150, on hepatic metastasis of the human colon carcinoma derived cell line, KM12-HX, which highly expresses sLeX antigen on the cell surface. "
3.	Carcinoma (Carcinomatosis) 03/01/2001 - "Anti-metastatic effect of the sialyl Lewis-X analog GSC-150 on the human colon carcinoma derived cell line KM12-HX in the mouse." 03/01/2001 - "We investigated the inhibitory effect of the sialyl Lewis-X (sLeX) analog, GSC-150, on hepatic metastasis of the human colon carcinoma derived cell line, KM12-HX, which highly expresses sLeX antigen on the cell surface. "

Related Drugs and Biologics

1.	Thymidine
2.	Lipopolysaccharides
3.	Antigens
4.	Sialyl Lewis X Antigen