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dioncophylline A

derived from the tropical vine Triphyophyllum peltatum; structure given in first source

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - dioncophylline A: 4

Experts

1.	Bringmann, Gerhard: 1 article (01/2017)
2.	Brun, Reto: 1 article (01/2017)
3.	Brünnert, Daniela: 1 article (01/2017)
4.	Chatterjee, Manik: 1 article (01/2017)
5.	Efferth, Thomas: 1 article (01/2017)
6.	Feineis, Doris: 1 article (01/2017)
7.	Kaiser, Marcel: 1 article (01/2017)
8.	Li, Jun: 1 article (01/2017)
9.	Mudogo, Virima: 1 article (01/2017)
10.	Seo, Ean-Jeong: 1 article (01/2017)

Related Diseases

1.	Multiple Myeloma 01/01/2017 - "Eight further known naphthylisoquinolines were isolated from A. ileboensis, among them dioncophylline A (P-10), its 4'-O-demethyl analogue P-11, and 5'-O-methyldioncophylline D (7), which were found to display strong cytotoxic activities against multiple myeloma INA-6 cells (P-10 even stronger than the standard drug melphalan) and against drug-sensitive acute lymphoblastic CCRF-CEM leukemia cells and their multidrug-resistant subline, CEM/ADR5000. "
2.	Malaria 11/01/1996 - "Larvicidal activity of the naphthylisoquinoline alkaloid dioncophylline A against the malaria vector Anopheles stephensi."
3.	Leukemia 01/01/2017 - "Eight further known naphthylisoquinolines were isolated from A. ileboensis, among them dioncophylline A (P-10), its 4'-O-demethyl analogue P-11, and 5'-O-methyldioncophylline D (7), which were found to display strong cytotoxic activities against multiple myeloma INA-6 cells (P-10 even stronger than the standard drug melphalan) and against drug-sensitive acute lymphoblastic CCRF-CEM leukemia cells and their multidrug-resistant subline, CEM/ADR5000. "
4.	Hepatocellular Carcinoma (Hepatoma) 01/01/1997 - "berghei-infected human hepatoma cells (Hep G2) were incubated with culture medium containing selected alkaloids at 10 micrograms/ml. The most active compounds, showing inhibitory activity of more than 40%, were dioncophylline A (compound 1), dioncophyllacine A (compound 6), and ancistrobarterine A (compound 12). "
5.	Body Weight (Weight, Body) 09/01/2006 - "The following pharmacokinetic parameters of dioncophylline A were determined: oral bioavailability of 25%, plasma half-life of 2.5 h and partition volume of 8 l kg-1 body weight. " 09/01/2006 - "Administration of dioncophylline A at a dose of 6.67 mg kg-1 body weight to rats intravenously and orally (n = 4 per group) resulted in peak plasma levels of 0.84 and 0.11 microg ml-1, respectively. "

Related Drugs and Biologics

1.	Alkaloids
2.	Melphalan (Alkeran)
3.	Dihydrotachysterol (AT 10)
4.	P 11 (P-11)