HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

XV 459

structure in first source

Also Known As:

N(3)-(2-(3-(4-formamidinophenyl)isoxazolin-5-yl)acetyl)-N(2)-(1-butyloxycarbonyl)-2,3-diaminopropionate; XV-459; XV459; hydrolyzed DMP 755

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - XV 459: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Isoxazoles: 155
      - XV 459: 3

Experts

1.	Ahmad, Sarfraz: 1 article (04/2007)
2.	Mousa, Shaker A: 1 article (04/2007)
3.	Barrett, Jeffrey S: 1 article (12/2002)
4.	Ebling, William F: 1 article (12/2002)
5.	Fossler, Michael J: 1 article (12/2002)
6.	Garner, Dennis: 1 article (12/2002)
7.	Kornhauser, David: 1 article (12/2002)
8.	Ma, Su: 1 article (12/2002)
9.	Mondick, John: 1 article (12/2002)
10.	Pieniaszek, Henry J: 1 article (12/2002)

Related Diseases

1.	Thrombosis (Thrombus) 10/01/1999 - "Additionally, both DMP754 and XV459 (0.1 mg/kg IV or 0.3 to 0.4 mg/kg PO) demonstrated maximal antithrombotic efficacy in preventing electrically induced carotid and coronary artery thrombosis and significant antithrombotic efficacy (P<0.001) at relatively low doses in different settings of arterial thrombosis in the canine model. " 10/01/1999 - "The present study was undertaken to determine intravenous and oral antithrombotic efficacies of DMP754 and XV459 and to compare them with those of other antiplatelet and anticoagulant agents in canine models of arterial thrombosis. "
2.	Peripheral Arterial Disease 12/01/2002 - "Roxifiban is an oral prodrug of XV459, a potent and specific inhibitor of the glycoprotein (GP) IIb/IIIa receptor previously under investigation for the treatment of peripheral arterial disease and acute coronary care syndrome. "
3.	Thrombocytopenia (Thrombopenia) 04/01/2007 - "Platelet GPIIb/IIIa antagonist, XV459, in heparin-induced thrombocytopenia." 04/01/2007 - "The platelet GPIIb/IIIa receptor antagonist (XV459) might be of potential benefit in the management of thrombotic thrombocytopenia produced by heparin and/or related glycosaminoglycans."

Related Drugs and Biologics

1.	Anticoagulants
2.	roxifiban acetate
3.	Platelet Membrane Glycoprotein IIb
4.	Prodrugs
5.	Heparin (Liquaemin)
6.	Glycosaminoglycans
7.	Glycoproteins (Glycoprotein)
8.	roxifiban