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4,6-dibromo-3-hydroxyanthranilic acid
Also Known As:
NCR 631; NCR-631
Networked:
2
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Benzoates: 426
Aminobenzoates: 1
ortho-Aminobenzoates: 8
3-Hydroxyanthranilic Acid: 78
4,6-dibromo-3-hydroxyanthranilic acid: 2
Carboxylic Acids: 973
Hydroxy Acids: 94
Hydroxybenzoates: 18
3-Hydroxyanthranilic Acid: 78
4,6-dibromo-3-hydroxyanthranilic acid: 2
Carbocyclic Acids
Benzoates: 426
Hydroxybenzoates: 18
3-Hydroxyanthranilic Acid: 78
4,6-dibromo-3-hydroxyanthranilic acid: 2
Aminobenzoates: 1
ortho-Aminobenzoates: 8
3-Hydroxyanthranilic Acid: 78
4,6-dibromo-3-hydroxyanthranilic acid: 2
Experts
1.
Luthman, J
: 1 article (01/2000)
Related Diseases
1.
Seizures (Absence Seizure)
01/01/2000 - "
Hence, the findings show that NCR-631 has anticonvulsant properties against generalized tonic-clonic seizures of different origin, suggesting that it may constitute a useful tool to study the role of kynurenines in various convulsive states.
"
01/01/2000 - "
In the present study, the anticonvulsant effect of the 3-HAO inhibitor NCR-631 was investigated in models of chemically- and sound-induced seizures.
"
01/01/2000 - "
Administration of NCR-631 i.c.v. at a dose of 300nmol in Sprague-Dawley rats was found to prolong the latency of occurrence of pentylenetetrazole (PTZ)-induced seizures.
"
2.
Hypoxia (Hypoxemia)
01/01/1998 - "
NCR-631 provided a concentration-dependent protective effect against the anoxia.
"
01/01/1998 - "
Effects of the 3-hydroxyanthranilic acid analogue NCR-631 on anoxia-, IL-1 beta- and LPS-induced hippocampal pyramidal cell loss in vitro.
"
Related Drugs and Biologics
1.
Anticonvulsants (Antiepileptic Drugs)
2.
Interleukin-1beta (Interleukin 1 beta)
3.
3-Hydroxyanthranilic Acid
4.
Pentylenetetrazole (Metrazol)