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E 4716

Also Known As:

1-(2-ethoxyethyl)-2-(4-(pyrazol-1-yl)piperazin-1-yl)benzimidazole dimaleate; E-4716

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - E 4716: 2

Related Diseases

1.	Bronchial Hyperreactivity 09/01/1996 - "E-4716 (300 microg/kg, i.v. or i.p.) suppressed histamine-induced bronchoconstriction in nonsensitized anesthetized guinea pigs and effectively inhibited acetylcholine-induced bronchial hyperreactivity in nonsensitized animals 24 h after PAF aerosol exposure. "
2.	Hypersensitivity (Allergy) 07/01/1996 - "The effects of E-4716 on chemical mediators were compared with those of classical antihistaminics and other second generation (nonsedating) drugs normally used in the therapy of allergic reactions, such as astemizole, terfenadine and ebastine, in a series of in vitro and in vivo tests. "
3.	Conjunctivitis 07/01/1996 - "E-4716 also inhibited the vascular permeability response in histamine-stimulated conjunctivitis model after topical ocular administration (ED50 = 0.002, 0.0002, 0.015 and 1.2% at 30 min and 6, 12 and 24 h, respectively). "

Related Drugs and Biologics

1.	Histamine (Histamine Dihydrochloride)
2.	Terfenadine (Seldane)
3.	Astemizole
4.	Histamine H1 Antagonists
5.	Aerosols
6.	Acetylcholine (Acetylcholine Chloride)
7.	ebastine (Kestin)

Related Therapies and Procedures

1.	Ophthalmic Administration
2.	Therapeutics