panamesine

Also Known As:

(5S)-5-((4-Hydroxy-4-(3,4-(methylenedioxy)phenyl)piperidino)methyl)-3-(p-methoxyphenyl)-2-oxazolidinone; 5-(4-hydroxy-4-(1,3-benzodioxol-5-yl)piperidine-1-ylmethyl)-3-(4-methoxyphenyl)oxazolidine-2-one hydrochloride; EMD 57445; EMD-57445

Networked: 7 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - panamesine: 7
  - Piperidines: 17
    - panamesine: 7

Related Diseases

Schizophrenia (Dementia Praecox)

07/01/1997 - "Here we report the results of an exploratory study aimed at determining the appropriate dose range and the safety of panamesine in patients with an acute episode of schizophrenia. "
12/27/1999 - "A 4-week open clinical study revealed only modest effects of EMD 57445 and its metabolites on positive and negative symptoms of schizophrenia. "
09/01/1999 - "The aim of this study was to test, using single photon emission computed tomography (SPECT) and [(123)I]iodobenzamide (IBZM) as the radiotracer, whether EMD 59983 would pass the blood-brain barrier and to what extent it would contribute to the effects of EMD 57445 in schizophrenia. "
08/01/1996 - "Since c-fos expression induced by EMD 57445 resembled the pattern obtained with atypical neuroleptics and studies on animal behavior point to antipsychotic activity, it is concluded that the drug might be suitable in the treatment of schizophrenia."
07/01/1997 - "Open clinical trial on the sigma ligand panamesine in patients with schizophrenia."

Related Drugs and Biologics

1.	Antipsychotic Agents (Antipsychotics)
2.	3- iodo- 2- hydroxy- 6- methoxy- N- ((1- ethyl- 2- pyrrolidinyl)methyl)benzamide
3.	panamesine
4.	Ligands
5.	sigma Receptors (sigma Receptor)
6.	Remoxipride
7.	eliprodil
8.	alpha- (4- fluorophenyl)- 4- (5- fluoro- 2- pyrimidinyl)- 1- piperazine butanol
9.	rimcazole