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trabecular meshwork-induced glucocorticoid response protein

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encodes a trabecular meshwork protein; causes primary open angle glaucoma; amino acid sequence known; GenBank R95491; RefSeq NM_000261 (human), NM_010865 (mouse), NM_030865 (rat)

Also Known As:

GLC1A protein; GLC1A protein, human; GLC1A protein, mouse; MYOC protein; MYOC protein, human; Myoc protein, mouse; Myoc protein, rat; TIGR protein; TIGR protein, human; TIGR protein, mouse; myocilin; myocilin protein, mouse; myocilin protein, rat; myocilin, trabecular meshwork inducible glucocorticoid response protein, human

Networked: 312 relevant articles (2 outcomes, 35 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Craig, Jamie E: 17 articles (08/2015 - 03/2002)
2.	Mackey, David A: 16 articles (08/2015 - 02/2003)
3.	Yue, Beatrice Y J T: 15 articles (01/2014 - 01/2002)
4.	Tomarev, Stanislav I: 14 articles (06/2015 - 06/2003)
5.	Lieberman, Raquel L: 11 articles (04/2015 - 05/2010)
6.	Tamm, Ernst R: 11 articles (08/2014 - 07/2002)
7.	Stone, Edwin M: 11 articles (03/2012 - 09/2002)
8.	Shen, Xiang: 10 articles (01/2014 - 07/2003)
9.	Ray, Kunal: 10 articles (01/2012 - 07/2002)
10.	Mukhopadhyay, Arijit: 9 articles (01/2010 - 07/2002)

Related Diseases

1.	Glaucoma 06/01/2013 - "The prevalence of Myocilin mutations in glaucoma cases with severe visual field loss is significantly greater than in nonadvanced glaucoma patients. " 12/01/2015 - "The purpose of this study was to discuss the benefits of predictive genetic testing in minors for Myocilin mutations associated with childhood onset glaucoma. " 03/01/2014 - "Here we review recent studies from our laboratory and those of others that deal with trabecular meshwork genes, which are altered by the overexpression of wild-type and glaucoma-causative mutant myocilin genes." 06/01/2013 - "Cell culture and mouse studies suggest that MYOC mutations cause glaucoma through a dominant-negative effect on myocilin protein secretion. " 01/01/2011 - "To date, genetic studies on glaucoma have revealed more than 20 gene loci and three candidate genes, myocilin (MYOC), optineurin (OPTN) and WD repeat domain 36 (WDR36). "
2.	Open-Angle Glaucoma (Glaucoma, Open Angle) 04/13/2012 - "Genetic studies have linked myocilin to open angle glaucoma, but the functions of the protein in the eye and other tissues have remained elusive. " 12/01/2009 - "In this study, we analyzed the localization of myocilin in the trabecular meshwork (TM) of eyes with primary open-angle glaucoma (POAG), and compared it with that of normal eyes. " 05/01/2008 - "This study determines myocilin protein levels in the aqueous humor (AH) of normal laboratory quality, genetic carrier (offspring of normal laboratory quality and POAG Beagles), and primary open angle glaucoma (POAG) Beagles. " 01/01/2008 - "Ongoing molecular genetic studies on myocilin and the search for new gene defects associated with JOAG may offer new directions in our scientific understanding and clinical management of open-angle glaucoma." 04/01/2007 - "To study the association between Myocilin (MYOC) Gln368STOP mutation and primary open angle glaucoma (POAG) by means of Meta-analysis. "
3.	Myopia 01/01/2007 - "To test the association between myocilin gene (MYOC) polymorphisms and high myopia in Hong Kong Chinese by using family-based association study. " 02/01/2009 - "Common variant in myocilin gene is associated with high myopia in isolated population of Korcula Island, Croatia." 01/01/2009 - "Myocilin polymorphisms and high myopia in subjects of European origin." 01/01/2007 - "Linkage and association of myocilin (MYOC) polymorphisms with high myopia in a Chinese population." 01/01/2009 - "Three previous studies have tested for an association between high myopia and polymorphisms in the open angle glaucoma gene, myocilin (MYOC), all in subjects of Chinese ethnicity. "
4.	Low Tension Glaucoma 04/01/2001 - "Although a normal tension glaucoma (NTG) patient with the myocilin gene mutation was previously reported, no study using large numbers of patients with NTG has been reported. " 11/01/2006 - "The presence of the Met98Lys variant was determined in a total of 498 (128 with normal-tension glaucoma (NTG)) patients with OAG, 29 patients who had myocilin-related OAG, 101 patients from ADOA pedigrees, 157 patients from LHON pedigrees and 218 examined OAG age-matched normal controls. " 01/01/2005 - "To determine the prevalence of optineurin (OPTN) and myocilin (MYOC) sequence variants in a cohort of German patients with normal tension glaucoma. " 01/01/2005 - "Prevalence of myocilin and optineurin sequence variants in German normal tension glaucoma patients." 11/01/2003 - "Variants of the myocilin gene in Japanese patients with normal-tension glaucoma."
5.	Angle-Closure Glaucoma (Glaucoma, Angle Closure) 01/01/2015 - "The aim of this study is to examine whether or not myocilin (MYOC) genetic variations are associated with susceptibility to primary angle-closure glaucoma (PACG) in the Han Chinese population. " 11/01/2007 - "The myocilin sequence of Shiba Inu dogs suggests that myocilin mutations are unlikely to play a significant role in the pathogenesis of primary closed-angle glaucoma in this breed. " 04/01/2005 - "Molecular analysis of the myocilin gene in Chinese subjects with chronic primary-angle closure glaucoma."

Related Drugs and Biologics

1.	glucose-regulated proteins
2.	Proteins (Proteins, Gene)
3.	cytochrome P-450 CYP1B1 (CYP1B1)
4.	Cytochrome P-450 Enzyme System (Cytochrome P450)
5.	Collagen Type I (Type I Collagen)
6.	Complementary DNA (cDNA)
7.	4-phenylbutyric acid (Buphenyl)
8.	olfactomedin
9.	Glycoproteins (Glycoprotein)
10.	Staphylococcal Protein A (A, Protein)

Related Therapies and Procedures

1.	Therapeutics
2.	Lenses