HLA-B57 antigen

11/01/2011 - "These findings are reminiscent of the selection of deleterious CTL escape and compensatory mutations by HLA-B57 in HIV-1 infection and, thus, may suggest a common mechanism by which alleles like HLA-B57 mediate protection against these highly variable pathogens."
01/01/2022 - "Certain CD8 T cell responses are particularly effective at controlling infection, as exemplified by elite control of HIV in individuals harboring HLA-B57. "
04/01/2019 - "Possible clearance of transfusion-acquired nef/LTR-deleted attenuated HIV-1 infection by an elite controller with CCR5 Δ32 heterozygous and HLA-B57 genotype."
03/01/2023 - "The protective impact of HLA-B*57:01/58:01 on CRF01_AE infection is impaired despite strong suppressive pressure by TW10-specific CD8+ T cells."
03/01/2023 - "Here, the effect of HLA-B*57:01/58:01 on CRF01_AE infection was investigated. "

05/01/2014 - "HLA-B*57:01 and HLA-B*57:03, the most prevalent HLA-B*57 subtypes in Caucasian and African populations, respectively, are the HLA alleles most protective against HIV disease progression. "
11/01/2013 - "However, there is considerable heterogeneity in HIV-1 disease progression rates among HLA-B*57-positive subjects, suggesting that additional factors may help to contain viral replication. "
01/01/2017 - "HLA-B*57 and IFNL4-related polymorphisms are associated with protection against HIV-1 disease progression in controllers."
10/01/2017 - "Relationship of Genotype for HLA B*57 and IFNL4 With Disease Progression in Female HIV Controllers."
11/19/2014 - "Fitness costs and slower disease progression are associated with a cytolytic T lymphocyte (CTL) escape mutation T242N in Gag in HIV-1-infected individuals carrying HLA-B*57/5801 alleles. "

09/01/2023 - "However, it is linked to a fatal hypersensitivity reaction in susceptible individuals, and is strongly associated with the HLA-B*57:01 allele. "
07/31/2023 - "These hypersensitivity reactions have been shown to be associated with the HLA-B*57:01 allele. "
11/08/2022 - "It is efficacious, but its use may be limited by a hypersensitivity reaction linked with the HLA-B*57:01 genotype. "
12/01/2021 - "ABC can trigger a severe hypersensitivity reaction in people who are homozygous or heterozygous for HLA-B*57:01. "
01/01/2019 - "Yearly incidence of both HLA-B*57:01 screening and physician panel-adjudicated hypersensitivity reactions were calculated and compared. "

01/01/2005 - "In Caucasoids and Africans, HLA-B57 and related alleles of the B58 supertype associate with low viraemia, delayed onset of AIDS and, possibly, cytotoxic T lymphocyte (CTL)-driven attenuation of HIV-1. "
11/23/2022 - "Rare HLA alleles such as HLA-B57 are associated with slow progression to AIDS. "
10/01/2013 - "HLA-B*57 is strongly associated with immune control of HIV and delayed AIDS progression. "
06/01/2011 - "The protective effect of HLA-B*57 on slow progression to AIDS and low VL may be mediated through its interaction with KIR3DL1 alleles to educate NK cells for potent activity upon stimulation."
01/01/2020 - "The aim of this study was to investigate demographic and immunovirological characteristics associated with psoriasis, and to assess whether HLA-B57:01 is associated with psoriasis among people living with HIV (PLHIV) followed in a large French multicenter Dat'AIDS cohort. "

10/31/2022 - "Protective HLA-B57: T cell and natural killer cell recognition in HIV infection."
01/01/2021 - "• HLA-B*57 modifies inflammatory subsets of NK cells and monocytes in HIV infection. "
01/01/2021 - "KEY MESSAGES: • HLA-B*57 is a host factor affecting clinical outcomes of HIV infection. "
01/01/2021 - "HLA-B*57 affects the course of HIV infection. "
10/01/2020 - "We included all outpatients aged >18 years old with HIV infection and known HLA-B*57:01 pattern, followed at our Department from January 2000 until December 2017. "