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FC 243
structure given in first source
Also Known As:
Arg-Gly-Asp-Ser-THFTCA conjugate; FC-243; THFTCA-(RDGS)3; tetrahydrofurantetracarboxylic acid-RGDS conjugate
Networked:
1
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Furans: 85
FC 243: 1
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
Oligopeptides: 519
FC 243: 1
Related Diseases
1.
Neoplasms (Cancer)
01/01/1995 - "
The in vitro tumor invasion study showed that FC-243 as well as RGDS+THFTCA on a molar basis resulted in similar inhibition of the invasion of B16-BL6 cells into reconstituted basement membrane Matrigel.
"
2.
Neoplasm Metastasis (Metastasis)
01/01/1995 - "
Intermittent IV administration of FC-243 after the inoculation of B16-BL6 cells caused significant inhibition of spontaneous lung metastasis as compared with multiple administration of RGDS or untreated control.
"
01/01/1995 - "
Combined treatment with FC-243 and DOX significantly inhibited lung metastasis of melanoma as compared with either treatment alone or the untreated control.
"
01/01/1995 - "
FC-243 showed an inhibitory effect on lung metastasis of melanoma cells in a dose-dependent manner.
"
01/01/1995 - "
A mixture of THFTCA and RGDS peptide or THFTCA alone did not show any inhibitory effect on experimental lung metastasis as compared with FC-243 on a molar basis.
"
01/01/1995 - "
tetrahydrofurantetracarboxylic acid (THFTCA)-RGDS conjugate [THFTCA- (RGDS)3, FC-243], and the inhibitory effect of FC-243 on lung metastasis of B16-BL6 melanoma in mice was examined in combination with or without the anticancer agent doxorubicin (DOX).
"
3.
Melanoma (Melanoma, Malignant)
01/01/1995 - "
Combined treatment with FC-243 and DOX significantly inhibited lung metastasis of melanoma as compared with either treatment alone or the untreated control.
"
01/01/1995 - "
FC-243 showed an inhibitory effect on lung metastasis of melanoma cells in a dose-dependent manner.
"
01/01/1995 - "
tetrahydrofurantetracarboxylic acid (THFTCA)-RGDS conjugate [THFTCA- (RGDS)3, FC-243], and the inhibitory effect of FC-243 on lung metastasis of B16-BL6 melanoma in mice was examined in combination with or without the anticancer agent doxorubicin (DOX).
"
Related Drugs and Biologics
1.
matrigel
2.
FC 243
3.
Doxorubicin (Adriamycin)
4.
Antineoplastic Agents (Antineoplastics)
5.
Acids
6.
arginyl-glycyl-aspartyl-serine