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6- cyano- 4- (N- ethylsulfonyl- N- methylamino)- 3- hydroxy- 2,2- dimethylchromane

Subscribe to New Research on 6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane

RN given for (trans-(+-))-isomer

Also Known As:

293B cpd; 6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane, (trans-(+))-isomer; 6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane, (trans-(-))-isomer; chromanol 293B

Networked: 7 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Taniguchi, Tomohiko: 1 article (03/2014)
2.	Suzuki, Tomoyuki: 1 article (03/2014)
3.	Shimizu, Takahiro: 1 article (03/2014)
4.	Miyamoto, Norimasa: 1 article (03/2014)
5.	Uesugi, Mai: 1 article (03/2014)
6.	Tsukada, Kazuhiro: 1 article (03/2014)
7.	Takahashi, Yuta: 1 article (03/2014)
8.	Sawada, Kohei: 1 article (03/2014)
9.	Takahashi, Yuji: 1 article (03/2014)
10.	Ojima, Atsuko: 1 article (03/2014)

Related Diseases

1.	Hypertrophy 03/01/2014 - "However, cells plated at low density had the following characteristics compared with those at high density: 1) significant enlargement in size; 2) significant increase or decrease in expression of the cardiac hypertrophy-characteristic genes NPPA, ATP2A2, ANKRD1 and MYL2 in accordance with the progression of hypertrophy; 3) significant reduction in responses to the inhibitors of cardiac slow delayed-rectifier K(+) current (IKs), chromanol 293B and HMR1556, in a cell-density-dependent manner; and 4) significant reduction in the expression of the KCNQ1 and KCNJ2 genes coding the K(+) ion channels conducting each IKs and cardiac inward rectifier outward K(+) current (IK1). "
2.	Cardiomegaly (Heart Hypertrophy) 03/01/2014 - "However, cells plated at low density had the following characteristics compared with those at high density: 1) significant enlargement in size; 2) significant increase or decrease in expression of the cardiac hypertrophy-characteristic genes NPPA, ATP2A2, ANKRD1 and MYL2 in accordance with the progression of hypertrophy; 3) significant reduction in responses to the inhibitors of cardiac slow delayed-rectifier K(+) current (IKs), chromanol 293B and HMR1556, in a cell-density-dependent manner; and 4) significant reduction in the expression of the KCNQ1 and KCNJ2 genes coding the K(+) ion channels conducting each IKs and cardiac inward rectifier outward K(+) current (IK1). "
3.	Atrial Fibrillation 07/08/2005 - "Whereas loss of KCNE1 function prolongs ventricular action potentials in humans, KCNE1-/- mice displayed unexpectedly shortened atrial action potentials, and multiple potential mechanisms were identified: (1) K+ currents (total and those sensitive to the KCNQ1 blocker chromanol 293B) were significantly increased in atrial cells from KCNE1-/- mice compared with controls, and (2) when CHO cells expressing KCNQ1 and KCNE1 were pulsed very rapidly (at rates comparable to the normal mouse heart and to human atrial fibrillation), the sigmoidicity of IKs activation prevented current accumulation, whereas cells expressing KCNQ1 alone displayed marked current accumulation at these very rapid rates. " 01/01/2004 - "Selective blockers (chromanol 293B, HMR-1556, L-735,821) of the KvLQT1 plus minK channel, which carriy the slow delayed rectifier potassium current (I(Ks)), were also considered to treat arrhythmias, including atrial fibrillation (AF). "
4.	Torsades de Pointes (Torsade de Pointes) 09/01/2009 - "Models of torsades de pointes: effects of FPL64176, DPI201106, dofetilide, and chromanol 293B in isolated rabbit and guinea pig hearts."
5.	Long QT Syndrome 10/09/2011 - "Quinidine, E4031 and chromanol 293B also decreased HR. Direct in-vitro recording of adult zebrafish heart is an efficient platform for test of drugs which exert electrophysiological effects on cardiomyocytes, and perturbation of ionic channels that are responsible for human long QT syndrome also modulates QT interval in adult zebrafish heart."

Related Drugs and Biologics

1.	Ion Channels (Ion Channel)
2.	N-propionylprocainamide
3.	Quinidine (Chinidin)
4.	Proteins (Proteins, Gene)
5.	Potassium
6.	HMR 1556
7.	L 735821
8.	FPL 64176
9.	dofetilide (Tikosyn)
10.	DPI 201-106