royleanone

from root of Salvia officinalis; structure given in first source

Also Known As:

12-hydroxy-8,12-abietadiene-11,14-dione; 1,4-Phenanthrenedione, 4b,5,6,7,8,8a,9,10-octahydro-3-hydroxy-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)-

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - Abietanes: 39
        royleanone: 3
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Phenanthrenes: 27
        Abietanes: 39
        royleanone: 3
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Phenanthrenes: 27
    - Abietanes: 39
      - royleanone: 3

Experts

1.	Alvarez-Manzaneda, Enrique: 1 article (12/2020)
2.	Chahboun, Rachid: 1 article (12/2020)
3.	Cirauqui, Nuria: 1 article (12/2020)
4.	Fernández, Antonio: 1 article (12/2020)
5.	Guardia, Juan J: 1 article (12/2020)
6.	Martín-Escolano, Javier: 1 article (12/2020)
7.	Martín-Escolano, Rubén: 1 article (12/2020)
8.	Marín, Clotilde: 1 article (12/2020)
9.	Rosales, Maria J: 1 article (12/2020)
10.	Sánchez-Moreno, Manuel: 1 article (12/2020)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 07/01/2018 - "Taken together, we propose that royleanone could prove to be an important anticancer lead molecule for the treatment and overall management of prostate cancer, provided further in vivo studies are carried out." 07/01/2018 - "Moreover, royleanone could also suppress the cell migration potential and inhibited the mTOR/ PI3/AKT signalling pathway in LNCaP prostate cancer cells. " 07/01/2018 - "The results showed that royleanone exerts potent anticancer activity on LNCaP prostate cancer cells with an IC50 of 12.5 μM at 48 hrs of incubation. " 07/01/2018 - "In the current study we evaluated the anticancer activity of royleanone diterpenoid against prostate cancer LNCaP cell line. "
2.	Pancreatic Neoplasms (Pancreatic Cancer) 06/01/2012 - "In the present study, five diterpenes, 7 alpha-acetoxyroyleanone, horminone, royleanone, 7-ketoroyleanone and sugiol which have been previously isolated from the medicinal plant Peltodon longipes were shown to possess cytotoxic activity against the human pancreatic cancer cell line MIA PaCa-2. "
3.	Necrosis 12/24/2020 - "In Vivo Biological Evaluation of a Synthetic Royleanone Derivative as a Promising Fast-Acting Trypanocidal Agent by Inducing Mitochondrial-Dependent Necrosis."
4.	Carcinoma (Carcinomatosis) 07/01/2018 - "Royleanone diterpenoid exhibits potent anticancer effects in LNCaP human prostate carcinoma cells by inducing mitochondrial mediated apoptosis, cell cycle arrest, suppression of cell migration and downregulation of mTOR/PI3K/AKT signalling pathway."

Related Drugs and Biologics

1.	Diterpenes
2.	sugiol
3.	horminone