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5- phenyl- 2- (2'- (benzimidazol- 5''- yl)benzimidazol- 5'- yl)benzimidazole

structure in first source

Also Known As:

5-phenylterbenzimidazole; 5PTB cpd

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - 5-phenyl-2-(2'-(benzimidazol-5''-yl)benzimidazol-5'-yl)benzimidazole: 3

Experts

1.	Kim, J S: 2 articles (11/2000 - 06/2000)
2.	Liu, A: 2 articles (11/2000 - 06/2000)
3.	Liu, L F: 2 articles (11/2000 - 06/2000)
4.	Rangarajan, M: 2 articles (11/2000 - 06/2000)
5.	Sim, S P: 2 articles (11/2000 - 06/2000)
6.	Lavoie, E J: 1 article (11/2000)
7.	Jin, S: 1 article (06/2000)
8.	LaVoie, E J: 1 article (06/2000)
9.	Pilch, D S: 1 article (06/2000)

Related Diseases

1.	Poisoning 11/01/2000 - "Significant enhancement in the topoisomerase I poisoning activity and cytotoxicity of 5-phenylterbenzimidazole is observed when the 2"-position is substituted with either a chloro or trifluoromethyl substituent. " 11/01/2000 - "The data indicate that such derivatives do retain similar topo I poisoning activity and possess cytotoxicity equivalent to either 5-bromo- or 5-phenylterbenzimidazole. " 11/01/2000 - "The 6-bromo, 6-methoxy, or 6-phenyl derivatives of both 5-bromo- and 5-phenylterbenzimidazole were synthesized and evaluated for topo I poisoning activity, as well as their cytotoxicity toward human lymphoblastoma cells. " 03/10/1998 - "We have employed a broad range of spectroscopic, calorimetric, DNA cleavage, and DNA winding/unwinding measurements to characterize the DNA binding and topoisomerase I (TOP1) poisoning properties of three terbenzimidazole analogues, 5-phenylterbenzimidazole (5PTB), terbenzimidazole (TB), and 5-(naphthyl[2,3-d]imidazo-2-yl)bibenzimidazole (5NIBB), which differ with respect to the substitutions at their C5 and/or C6 positions. "
2.	Neoplasms (Cancer) 06/01/2000 - "5-Phenylterbenzimidazole (1) is active as a topoisomerase I poison (topo I) and is cytotoxic to human tumor cells. "

Related Drugs and Biologics

1.	Type I DNA Topoisomerases (Topoisomerase I)
2.	trioctyl phosphine oxide (TOPO)
3.	Poisons
4.	DNA (Deoxyribonucleic Acid)